[对生物三维打印技术创造的三维细胞产品世界和生命科学领域的贡献]。

Toshihiko Maekawa
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引用次数: 0

摘要

我们秉承 "通过实际应用创新的三维细胞堆积技术,为医疗领域的巨大进步做出贡献 "的企业理念,一直致力于制造仅由细胞构成的三维组织。目前,在再生医学领域,我们正致力于获得厚生劳动省的批准,并将由患者自身细胞制成的具有神经再生、骨软骨再生和血管等功能的大型人工器官商业化。另一方面,这种三维细胞堆积技术可以扩展到在类似人体的环境中培养细胞的技术,有望成为评估各领域新产品对生物体影响的新方法。因此,我们正计划开展一项业务,为药品、食品、化妆品等开发商提供一种被称为 "功能细胞设备(FCD)"的小型装置,这种装置可以在体外再现人体器官的部分功能。作为第一步,我们开发了一种三维肝脏构建体(三维迷你肝脏)。体外人体肝脏模型用途广泛,如评估药物的肝毒性、阐明药物代谢机制和肝病模型等。在本报告中,我们将结合再生医学中的实际案例对其进行概述。
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[Contribution to the world of 3D cell products created by bio 3D printing technology and to the life science field].

We have been making 3D tissues consist of cells only, based on the corporate philosophy of "contributing to dramatic advances in medical care through the practical application of innovative 3D cell stacking technology." Currently, in the field of regenerative medicine, we are working toward obtaining approval from the Ministry of Health, Labor and Welfare and commercializing large artificial organs that are made from patients' own cells and have functions such as nerve regeneration, osteochondral regeneration, and blood vessels. On the other hand, this three-dimensional cell stacking technology can be extended to technology for culturing cells in an environment similar to the human body, and is expected to serve as a new methodology for evaluating the effects of new products in various fields on living organisms. Therefore, we are planning a business to provide developers of pharmaceuticals, foods, cosmetics, etc. with a small device called "Functional Cell Device (FCD)" that reproduces some of the functions of human organs outside the body. As the first step, we have developed a three-dimensional liver construct (3D mini-liver). The in vitro human liver model has a wide range of usage, such as evaluation of hepatotoxicity of drugs, elucidation of drug metabolism mechanism, and model of liver disease. In this report, we will outline it together with actual examples in regenerative medicine.

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来源期刊
Folia Pharmacologica Japonica
Folia Pharmacologica Japonica Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
132
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