与转诊接受直接观察治疗和治疗不成功相关的因素。

IF 3.4 3区 医学 Q2 INFECTIOUS DISEASES International Journal of Tuberculosis and Lung Disease Pub Date : 2024-05-01 DOI:10.5588/ijtld.23.0396
Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet
{"title":"与转诊接受直接观察治疗和治疗不成功相关的因素。","authors":"Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet","doi":"10.5588/ijtld.23.0396","DOIUrl":null,"url":null,"abstract":"<p><p><sec id=\"st1\"><title>OBJECTIVE</title>To describe the characteristics of people indicated for directly observed treatment (DOT) in Spain, and the factors associated with unsuccessful treatment.</sec><sec id=\"st2\"><title>METHODS</title>This was a multicentre observational study based on a prospective follow-up of patients over 18 years old diagnosed with TB between 2006 and 2019 from the registry of the Programa Integrado de Investigación en Tuberculosis (PII-TB). Sociodemographic and clinical variables were collected. Adjusted odds ratios (aORs) were calculated for the indication of DOT and for having an unsuccessful treatment.</sec><sec id=\"st3\"><title>RESULTS</title>A total of 7,883 patients were included. The indication of DOT was associated with being homeless (aOR 5.93, 95% CI 3.03-11.59), inactivity status (aOR 2.55, 95% CI 2.02-3.23), alcohol consumption (aOR 1.94, 95% CI 1.51-2.48), parenteral drug use (aOR 1.77, 95% CI 1.06-2.95) and HIV diagnosis (aOR 1.96, 95% CI 1.16-3.29). Unsuccessful treatment was associated with having an HIV diagnosis (aPR 2.31, 95% CI 1.31-4.08), having a worse clinical and radiological evolution (clinical progression: APR 15.59, 95% CI 8.21-29.60; radiological progression: aPR 12.84, 95% CI 6.46-25.52), need for hospitalisation (aPR 1.73, 95% CI 1.10-2.73), unsatisfactory tolerability (aPR 2.82, 95% CI 1.49-5.29), the existence of difficulties in understanding the prescribed treatment (aPR 1.92, 95% CI 1.21-3.06), as well as worse treatment satisfaction (aPR 7.27, 95% CI 4.32-12.24).</sec><sec id=\"st4\"><title>CONCLUSION</title>The prioritisation of vulnerable populations is a key aspect to carry out the new Global Plan to End TB 2023-2030. In these groups DOT indication should be increased to ensure adherence and patient follow-up and outcomes.</sec>.</p>","PeriodicalId":14411,"journal":{"name":"International Journal of Tuberculosis and Lung Disease","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Factors associated with referrals for directly observed treatment and unsuccessful treatment.\",\"authors\":\"Y D González Diaz, D Palma, H Vargas-Leguás, T Rodrigo, I Molina-Pinargorte, X Casas, N Forcada, J Santiago, N Altet, J-P Millet\",\"doi\":\"10.5588/ijtld.23.0396\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><sec id=\\\"st1\\\"><title>OBJECTIVE</title>To describe the characteristics of people indicated for directly observed treatment (DOT) in Spain, and the factors associated with unsuccessful treatment.</sec><sec id=\\\"st2\\\"><title>METHODS</title>This was a multicentre observational study based on a prospective follow-up of patients over 18 years old diagnosed with TB between 2006 and 2019 from the registry of the Programa Integrado de Investigación en Tuberculosis (PII-TB). Sociodemographic and clinical variables were collected. Adjusted odds ratios (aORs) were calculated for the indication of DOT and for having an unsuccessful treatment.</sec><sec id=\\\"st3\\\"><title>RESULTS</title>A total of 7,883 patients were included. The indication of DOT was associated with being homeless (aOR 5.93, 95% CI 3.03-11.59), inactivity status (aOR 2.55, 95% CI 2.02-3.23), alcohol consumption (aOR 1.94, 95% CI 1.51-2.48), parenteral drug use (aOR 1.77, 95% CI 1.06-2.95) and HIV diagnosis (aOR 1.96, 95% CI 1.16-3.29). Unsuccessful treatment was associated with having an HIV diagnosis (aPR 2.31, 95% CI 1.31-4.08), having a worse clinical and radiological evolution (clinical progression: APR 15.59, 95% CI 8.21-29.60; radiological progression: aPR 12.84, 95% CI 6.46-25.52), need for hospitalisation (aPR 1.73, 95% CI 1.10-2.73), unsatisfactory tolerability (aPR 2.82, 95% CI 1.49-5.29), the existence of difficulties in understanding the prescribed treatment (aPR 1.92, 95% CI 1.21-3.06), as well as worse treatment satisfaction (aPR 7.27, 95% CI 4.32-12.24).</sec><sec id=\\\"st4\\\"><title>CONCLUSION</title>The prioritisation of vulnerable populations is a key aspect to carry out the new Global Plan to End TB 2023-2030. In these groups DOT indication should be increased to ensure adherence and patient follow-up and outcomes.</sec>.</p>\",\"PeriodicalId\":14411,\"journal\":{\"name\":\"International Journal of Tuberculosis and Lung Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Tuberculosis and Lung Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5588/ijtld.23.0396\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Tuberculosis and Lung Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5588/ijtld.23.0396","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

目的描述西班牙接受直接观察治疗(DOT)者的特征,以及与治疗不成功相关的因素。方法这是一项多中心观察性研究,基于对 2006 年至 2019 年期间从结核病综合研究计划(PII-TB)登记处确诊的 18 岁以上结核病患者的前瞻性随访。研究收集了社会人口学和临床变量。结果共纳入 7883 名患者。DOT 的适应症与无家可归(aOR 5.93,95% CI 3.03-11.59)、不活动状态(aOR 2.55,95% CI 2.02-3.23)、饮酒(aOR 1.94,95% CI 1.51-2.48)、使用肠外药物(aOR 1.77,95% CI 1.06-2.95)和 HIV 诊断(aOR 1.96,95% CI 1.16-3.29)有关。治疗不成功与以下因素有关:HIV 诊断(aPR 2.31,95% CI 1.31-4.08)、临床和放射学进展恶化(临床进展:APR 15.59,95% CI 1.31-4.08):APR15.59,95% CI 8.21-29.60;放射学进展:aPR 12.84,95% CI 6.46-25.52)、需要住院(aPR 1.73,95% CI 1.10-2.73)、耐受性不满意(aPR 2.82,95% CI 1.49-5.29)、难以理解处方治疗(aPR 1.结论:优先考虑易感人群是实施新的《2023-2030 年终结结核病全球计划》的一个关键方面。在这些人群中,应增加直接观察治疗的适应症,以确保患者坚持治疗,并对患者进行随访和取得疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Factors associated with referrals for directly observed treatment and unsuccessful treatment.

OBJECTIVETo describe the characteristics of people indicated for directly observed treatment (DOT) in Spain, and the factors associated with unsuccessful treatment.METHODSThis was a multicentre observational study based on a prospective follow-up of patients over 18 years old diagnosed with TB between 2006 and 2019 from the registry of the Programa Integrado de Investigación en Tuberculosis (PII-TB). Sociodemographic and clinical variables were collected. Adjusted odds ratios (aORs) were calculated for the indication of DOT and for having an unsuccessful treatment.RESULTSA total of 7,883 patients were included. The indication of DOT was associated with being homeless (aOR 5.93, 95% CI 3.03-11.59), inactivity status (aOR 2.55, 95% CI 2.02-3.23), alcohol consumption (aOR 1.94, 95% CI 1.51-2.48), parenteral drug use (aOR 1.77, 95% CI 1.06-2.95) and HIV diagnosis (aOR 1.96, 95% CI 1.16-3.29). Unsuccessful treatment was associated with having an HIV diagnosis (aPR 2.31, 95% CI 1.31-4.08), having a worse clinical and radiological evolution (clinical progression: APR 15.59, 95% CI 8.21-29.60; radiological progression: aPR 12.84, 95% CI 6.46-25.52), need for hospitalisation (aPR 1.73, 95% CI 1.10-2.73), unsatisfactory tolerability (aPR 2.82, 95% CI 1.49-5.29), the existence of difficulties in understanding the prescribed treatment (aPR 1.92, 95% CI 1.21-3.06), as well as worse treatment satisfaction (aPR 7.27, 95% CI 4.32-12.24).CONCLUSIONThe prioritisation of vulnerable populations is a key aspect to carry out the new Global Plan to End TB 2023-2030. In these groups DOT indication should be increased to ensure adherence and patient follow-up and outcomes..

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.90
自引率
20.00%
发文量
266
审稿时长
2 months
期刊介绍: The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
期刊最新文献
Building social equity and person-centred innovation into the end TB response. Cascade of care for TB infection in persons newly diagnosed with HIV in Italy. Clinical characteristics and decortication outcomes of bacterial, tuberculous and fungal pleural infection. Impact of hyponatraemia during exacerbation on clinical outcomes in patients with bronchiectasis. Omadacycline enhances the in vitro activity of clofazimine against Mycobacterium abscessus.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1