有合并症和无合并症的 2 型糖尿病患者的生物标志物比较分析:洞察高血压和心血管疾病的作用。

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Insights Pub Date : 2024-05-04 eCollection Date: 2024-01-01 DOI:10.1177/11772719231222111
Symeon Savvopoulos, Haralampos Hatzikirou, Herbert F Jelinek
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引用次数: 0

摘要

背景:2 型糖尿病(T2DM)占糖尿病病例的 90%,其患病率和发病率(包括合并症)在全球范围内呈上升趋势。临床上,糖尿病和相关合并症可通过生化和物理特征(包括血糖、糖化血红蛋白(HbA1c)以及心血管、眼部和肾脏疾病检测)来识别:糖尿病可能具有基于炎症和氧化应激的共同病因,这可能提供有关疾病进展和治疗方案的更多信息。因此,识别高危人群可以延缓或预防糖尿病及其并发症:设计:在患有或不患有高血压和心血管疾病的患者中,作为从无糖尿病到 T2DM 进展的一部分,本研究调查了糖尿病控制期与糖尿病前期、糖尿病前期与 T2DM、糖尿病控制期与 T2DM 之间生物标志物的变化,并根据首次就诊数据对患者进行了分类。对照组患者和高血压、心血管以及同时患有高血压和心血管疾病的患者分别为 156 人、148 人、61 人和 216 人:本研究考察了人血清素与线粒体蛋白(MOTSc)、与氧化应激相关的线粒体肽、糖尿病进展及相关并发症之间的关系:结果:MOTSc、还原型谷胱甘肽和谷胱甘肽二硫化物比率(GSH/GSSG)、白细胞介素-1β(IL-1β)和8-异前列腺素均有显著性差异(P随着糖尿病的发展,合并症会影响假设的生物标志物。线粒体氧化应激指标、凝血和炎症标志物有助于评估糖尿病疾病的发展并提供适当的药物。未来的研究将考察生物标志物的纵向演变。
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Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease.

Background: Type 2 diabetes mellitus (T2DM) are 90% of diabetes cases, and its prevalence and incidence, including comorbidities, are rising worldwide. Clinically, diabetes and associated comorbidities are identified by biochemical and physical characteristics including glycemia, glycated hemoglobin (HbA1c), and tests for cardiovascular, eye and kidney disease.

Objectives: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. Thus, identifying high-risk individuals can delay or prevent diabetes and its complications.

Design: In patients with or without hypertension and cardiovascular disease, as part of progression from no diabetes to T2DM, this research studied the changes in biomarkers between control and prediabetes, prediabetes to T2DM, and control to T2DM, and classified patients based on first-attendance data. Control patients and patients with hypertension, cardiovascular, and with both hypertension and cardiovascular diseases are 156, 148, 61, and 216, respectively.

Methods: Linear discriminant analysis is used for classification method and feature importance, This study examined the relationship between Humanin and mitochondrial protein (MOTSc), mitochondrial peptides associated with oxidative stress, diabetes progression, and associated complications.

Results: MOTSc, reduced glutathione and glutathione disulfide ratio (GSH/GSSG), interleukin-1β (IL-1β), and 8-isoprostane were significant (P < .05) for the transition from prediabetes to t2dm, highlighting importance of mitochondrial involvement. complement component 5a (c5a) is a biomarker associated with disease progression and comorbidities, gsh gssg, monocyte chemoattractant protein-1 (mcp-1), 8-isoprostane being most important biomarkers.

Conclusions: Comorbidities affect the hypothesized biomarkers as diabetes progresses. Mitochondrial oxidative stress indicators, coagulation, and inflammatory markers help assess diabetes disease development and provide appropriate medications. Future studies will examine longitudinal biomarker evolution.

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来源期刊
Biomarker Insights
Biomarker Insights MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.00
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
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