具有热离子效应的铜氧化物/硬石膏/精氨酸复合水凝胶用于治疗种植体周围病变。

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Regenerative Biomaterials Pub Date : 2024-03-21 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae028
Yiru Xia, Zhaowenbin Zhang, Kecong Zhou, Zhikai Lin, Rong Shu, Yuze Xu, Zhen Zeng, Jiang Chang, Yufeng Xie
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引用次数: 0

摘要

种植体周围病变是困扰众多种植牙患者的一种严重疾病。它是由于持续的牙周细菌积聚造成种植体周围发炎,主要导致种植体松动,最终导致种植体脱落。早期的种植体周围病变表现出类似牙龈疾病的症状,包括种植体周围牙龈肿胀、发红和出血。这些症状表明种植体周围组织受到感染和发炎,可能导致骨质流失和种植失败。为了解决这个问题,我们采用了一种热离子策略,设计了一种具有光热和 Cu/Zn/Si 多离子释放特性的铜氧化物-霞石生物陶瓷/精氨酸复合水凝胶。这种创新方法通过从复合水凝胶中释放生物活性离子(Cu2+、Zn2+ 和 SiO32-)以及复合水凝胶在近红外线照射下诱导的光热效应产生温和的热环境,从而产生热离子效应。这种热效应最显著的优点是能大量消除牙周致病菌和抑制炎症,同时增强种植体周围的骨结合。这种独特的特性使得这种复合水凝胶的使用非常有效,可以在干预种植体周围病变后显著提高种植体的存活率,而这正是牙周病学中的一个临床难题。这项研究揭示了一种新型生物材料治疗种植体周围病变的应用潜力,因为它不仅能消除感染和炎症,还能增强牙种植体的骨结合,这为利用生物活性功能材料预防和处理早期种植体周围病变提供了理论启示和实践指导。
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Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion.

Peri-implant lesion is a grave condition afflicting numerous indi-viduals with dental implants. It results from persistent periodontal bacteria accumulation causing inflammation around the implant site, which can primarily lead to implant loosening and ultimately the implant loss. Early-stage peri-implant lesions exhibit symptoms akin to gum disease, including swelling, redness and bleeding of the gums surrounding the implant. These signs indicate infection and inflammation of the peri-implant tissues, which may result in bone loss and implant failure. To address this problem, a thermionic strategy was applied by designing a cuprorivaite-hardystonite bioceramic/alginate composite hydrogel with photothermal and Cu/Zn/Si multiple ions releasing property. This innovative approach creates a thermionic effect by the release of bioactive ions (Cu2+ and Zn2+ and SiO32-) from the composite hydrogel and the mild heat environment though the photothermal effect of the composite hydrogel induced by near-infrared light irradiation. The most distinctive advantage of this thermionic effect is to substantially eliminate periodontal pathogenic bacteria and inhibit inflammation, while simultaneously enhance peri-implant osseointegration. This unique attribute renders the use of this composite hydrogel highly effective in significantly improving the survival rate of implants after intervention in peri-implant lesions, which is a clinical challenge in periodontics. This study reveals application potential of a new biomaterial-based approach for peri-implant lesion, as it not only eliminates the infection and inflammation, but also enhances the osteointegration of the dental implant, which provides theoretical insights and practical guidance to prevent and manage early-stage peri-implant lesion using bioactive functional materials.

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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
期刊最新文献
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