释放纳米医学的力量:用于癌症治疗的细胞膜衍生生物仿生癌症纳米疫苗。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Med Pub Date : 2024-07-12 Epub Date: 2024-04-05 DOI:10.1016/j.medj.2024.03.012
Guo Zhao, Shuhang Wang, Guangjun Nie, Ning Li
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引用次数: 0

摘要

过去几十年来,纳米医学研究人员一直致力于开发能够更精确地输送药物载荷以攻击肿瘤的纳米级平台。癌症纳米疫苗在诱导肿瘤特异性抗肿瘤反应方面表现出与众不同的能力。然而,要使癌症纳米疫苗产生足够的治疗效果,仍有许多难题需要解决。细胞膜衍生纳米疫苗是一类新兴的癌症疫苗,由天然衍生细胞膜伪装的合成纳米级核心组成。特定的细胞膜具有生物仿生纳米形态,具有多种独特的能力,如免疫逃避、增强生物相容性和肿瘤靶向等,通常与源细胞相关。在此,我们将讨论细胞膜衍生纳米疫苗的进展以及这些疫苗如何用于癌症治疗。转化工作目前正在进行中,还需要开展更多的研究来有效解决关键领域的需求,从而促进这些新兴疫苗平台未来的成功转化。
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Unlocking the power of nanomedicine: Cell membrane-derived biomimetic cancer nanovaccines for cancer treatment.

Over the past decades, nanomedicine researchers have dedicated their efforts to developing nanoscale platforms capable of more precisely delivering drug payloads to attack tumors. Cancer nanovaccines are exhibiting a distinctive capability in inducing tumor-specific antitumor responses. Nevertheless, there remain numerous challenges that must be addressed for cancer nanovaccines to evoke sufficient therapeutic effects. Cell membrane-derived nanovaccines are an emerging class of cancer vaccines that comprise a synthetic nanoscale core camouflaged by naturally derived cell membranes. The specific cell membrane has a biomimetic nanoformulation with several distinctive abilities, such as immune evasion, enhanced biocompatibility, and tumor targeting, typically associated with a source cell. Here, we discuss the advancements of cell membrane-derived nanovaccines and how these vaccines are used for cancer therapeutics. Translational endeavors are currently in progress, and additional research is also necessary to effectively address crucial areas of demand, thereby facilitating the future successful translation of these emerging vaccine platforms.

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来源期刊
Med
Med MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
17.70
自引率
0.60%
发文量
102
期刊介绍: Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.
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