波士顿海湾战争疾病生物库和综合网络中 1991 年海湾战争女退伍军人的特征:人口统计学、暴露、神经影像学和认知结果。

IF 3 3区 心理学 Q2 CLINICAL NEUROLOGY Clinical Neuropsychologist Pub Date : 2024-08-01 Epub Date: 2024-05-01 DOI:10.1080/13854046.2024.2344263
Maxine Krengel, Dylan Keating, Linda Chao, Julianne Dugas, BangBon Koo, Timothy Heeren, Emily Quinn, Rosemary Toomey, Lea Steele, Nancy Klimas, Francis Samonte, Laila Abdullah, Kimberly Sullivan
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引用次数: 0

摘要

目的:海湾战争病(GWI)是一种使人衰弱的多症状疾病,1990-91 年海湾战争(GW)退伍军人中近三分之一的人患有此病。症状包括疼痛、疲劳、肠胃问题和认知能力下降。我们的工作表明,男性和女性退伍军人的海湾战争感染率和症状的潜在原因各不相同。研究记录的神经心理学和神经影像学发现大多是男性或男女混合数据集。由于缺乏女性退伍军人样本的研究力量和资料库,因此缺乏女性退伍军人的数据。研究方法:我们从新近整理的波士顿生物储存和整合网络(BBRAIN)中的人口统计学、暴露、神经心理学和神经影像学结果等方面描述了 GWI 女性退伍军人的特征。研究结果BBRAIN 女退伍军人受过高等教育,平均年龄 54 岁。81% 的人符合 GWI 标准,25% 的人符合当前创伤后应激障碍的标准,78% 的人是白人,81% 的人曾在军队服役。与未接触过乙酰胆碱酯酶抑制剂(AChEi)的女性相比,接触过乙酰胆碱酯酶抑制剂(AChEi)(包括皮肤杀虫剂、烟雾/喷雾和/或溴化吡啶斯的明(PB)抗神经毒气药片)的女性在注意力任务上的处理速度较慢,并有执行力受损的趋势。脑成像结果表明,暴露妇女的灰质体积较低,尾状体较小。结论:尽管在这组女性退伍军人中发现了微妙而有限的结果,但这表明有必要继续对 GW 女性退伍军人进行跟踪调查。未来的研究应继续评估全球战略退伍军人样本中男女之间的差异。BBRAIN 女性子库正在招募人员,研究界可利用这些数据对女性退伍军人进行研究。
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Characterizing 1991 Gulf War women veterans from the Boston Biorepository and Integrative Network for Gulf War Illness: Demographics, exposures, neuroimaging and cognitive outcomes.

Objective: Gulf War Illness (GWI) is a debilitating multisymptom condition that affects nearly a third of 1990-91 Gulf War (GW) veterans. Symptoms include pain, fatigue, gastrointestinal issues, and cognitive decrements. Our work has shown that GWI rates and potential causes for symptoms vary between men and women veterans. Studies have documented neuropsychological and neuroimaging findings mostly in men or combined sex datasets. Data are lacking for women veterans due to lack of power and repositories of women veteran samples. Methods: We characterized GW women veterans in terms of demographics, exposures, neuropsychological and neuroimaging outcomes from the newly collated Boston, Biorepository and Integrative Network (BBRAIN) for GWI. Results: BBRAIN women veterans are highly educated with an average age of 54 years. 81% met GWI criteria, 25% met criteria for current PTSD, 78% were white, and 81% served in the Army. Exposure to combined acetylcholinesterase inhibitors (AChEi) including skin pesticides, fogs/sprays and/or pyridostigmine bromide (PB) anti-nerve gas pill exposure resulted in slower processing speed on attentional tasks and a trend for executive impairment compared with non-exposed women. Brain imaging outcomes showed lower gray matter volumes and smaller caudate in exposed women. Conclusions: Although subtle and limited findings were present in this group of women veterans, it suggests that continued follow-up of GW women veterans is warranted. Future research should continue to evaluate differences between men and women in GW veteran samples. The BBRAIN women sub-repository is recruiting and these data are available to the research community for studies of women veterans.

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来源期刊
Clinical Neuropsychologist
Clinical Neuropsychologist 医学-临床神经学
CiteScore
8.40
自引率
12.80%
发文量
61
审稿时长
6-12 weeks
期刊介绍: The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.
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