多灶性婴儿血管瘤--4 例病例介绍及文献综述。

Aleksandra Matić, Milan Matić, Sonja Prćić, Anica Radulović, Miloš Pajić, Milica Žeravica
{"title":"多灶性婴儿血管瘤--4 例病例介绍及文献综述。","authors":"Aleksandra Matić, Milan Matić, Sonja Prćić, Anica Radulović, Miloš Pajić, Milica Žeravica","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Multifocal infantile hemangiomas (IHs) are focal cutaneous lesions affecting more than 1 anatomic site. The multifocal distribution pattern is the rarest form of IH manifestation, accounting for only 3-4% of all affected infants. This type of cutaneous IHs may be a marker for extracutaneous disease, with the liver being the most frequently affected organ.</p><p><strong>Methods: </strong>We investigated the clinical and epidemiological characteristics of a small case series of infants with multifocal IHs presenting with different clinical patterns, all diagnosed and treated in a regional tertiary-care pediatric clinic.</p><p><strong>Results: </strong>Four infants with multifocal IHs were included in the analysis. There were 3 girls and 1 boy. Three out of 4 infants were prematurely born (2 of them very preterm), while only 1 was full-term. Clinical patterns in all cases were quite different, but more than 20 cutaneous IHs were present in each of the patients. Two infants had multifocal liver hemangioma, but without complications. In 3 out of 4 patients, systemic propranolol therapy was introduced, with excellent response in two cases (both with liver involvement).</p><p><strong>Conclusion: </strong>With the increase in the number of cutaneous IHs, the probability of internal organ involvement, most often the liver, also increases. Evaluation for extracutaneous lesions is indicated in infants with 5 or more cutaneous IHs. Treatment of infants with multifocal IHs should be individualized and consider all relevant risk factors, including prematurity.</p>","PeriodicalId":94367,"journal":{"name":"Acta dermatovenerologica Croatica : ADC","volume":"31 4","pages":"208-212"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multifocal Infantile Hemangioma - Presentation of 4 Cases and Review of the Selected Literature.\",\"authors\":\"Aleksandra Matić, Milan Matić, Sonja Prćić, Anica Radulović, Miloš Pajić, Milica Žeravica\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Multifocal infantile hemangiomas (IHs) are focal cutaneous lesions affecting more than 1 anatomic site. The multifocal distribution pattern is the rarest form of IH manifestation, accounting for only 3-4% of all affected infants. This type of cutaneous IHs may be a marker for extracutaneous disease, with the liver being the most frequently affected organ.</p><p><strong>Methods: </strong>We investigated the clinical and epidemiological characteristics of a small case series of infants with multifocal IHs presenting with different clinical patterns, all diagnosed and treated in a regional tertiary-care pediatric clinic.</p><p><strong>Results: </strong>Four infants with multifocal IHs were included in the analysis. There were 3 girls and 1 boy. Three out of 4 infants were prematurely born (2 of them very preterm), while only 1 was full-term. Clinical patterns in all cases were quite different, but more than 20 cutaneous IHs were present in each of the patients. Two infants had multifocal liver hemangioma, but without complications. In 3 out of 4 patients, systemic propranolol therapy was introduced, with excellent response in two cases (both with liver involvement).</p><p><strong>Conclusion: </strong>With the increase in the number of cutaneous IHs, the probability of internal organ involvement, most often the liver, also increases. Evaluation for extracutaneous lesions is indicated in infants with 5 or more cutaneous IHs. Treatment of infants with multifocal IHs should be individualized and consider all relevant risk factors, including prematurity.</p>\",\"PeriodicalId\":94367,\"journal\":{\"name\":\"Acta dermatovenerologica Croatica : ADC\",\"volume\":\"31 4\",\"pages\":\"208-212\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta dermatovenerologica Croatica : ADC\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta dermatovenerologica Croatica : ADC","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:多灶性婴儿血管瘤(IHs)是影响一个以上解剖部位的局灶性皮肤病变。多灶分布模式是最罕见的 IH 表现形式,仅占所有患病婴儿的 3-4%。这种类型的皮肤 IH 可能是皮肤外疾病的标志,肝脏是最常受影响的器官:我们调查了一个小型病例系列的临床和流行病学特征,这些婴儿患有多灶性 IHs,表现出不同的临床模式,均在一家地区三级儿科诊所接受诊断和治疗:结果:4名患有多灶性IH的婴儿被纳入分析范围。其中有 3 名女孩和 1 名男孩。4 名婴儿中有 3 名是早产儿(其中 2 名是极早产儿),只有 1 名是足月儿。所有病例的临床模式大相径庭,但每个患者都有超过 20 个皮肤 IHs。两名婴儿患有多灶性肝血管瘤,但没有并发症。4 例患者中有 3 例接受了全身普萘洛尔治疗,其中 2 例反应良好(均累及肝脏):结论:随着皮肤血管瘤数量的增加,内脏器官(最常见的是肝脏)受累的可能性也在增加。对于有 5 个或 5 个以上皮肤 IH 的婴儿,应进行皮肤外病变评估。多灶性 IH 婴儿的治疗应个体化,并考虑所有相关的风险因素,包括早产。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Multifocal Infantile Hemangioma - Presentation of 4 Cases and Review of the Selected Literature.

Background: Multifocal infantile hemangiomas (IHs) are focal cutaneous lesions affecting more than 1 anatomic site. The multifocal distribution pattern is the rarest form of IH manifestation, accounting for only 3-4% of all affected infants. This type of cutaneous IHs may be a marker for extracutaneous disease, with the liver being the most frequently affected organ.

Methods: We investigated the clinical and epidemiological characteristics of a small case series of infants with multifocal IHs presenting with different clinical patterns, all diagnosed and treated in a regional tertiary-care pediatric clinic.

Results: Four infants with multifocal IHs were included in the analysis. There were 3 girls and 1 boy. Three out of 4 infants were prematurely born (2 of them very preterm), while only 1 was full-term. Clinical patterns in all cases were quite different, but more than 20 cutaneous IHs were present in each of the patients. Two infants had multifocal liver hemangioma, but without complications. In 3 out of 4 patients, systemic propranolol therapy was introduced, with excellent response in two cases (both with liver involvement).

Conclusion: With the increase in the number of cutaneous IHs, the probability of internal organ involvement, most often the liver, also increases. Evaluation for extracutaneous lesions is indicated in infants with 5 or more cutaneous IHs. Treatment of infants with multifocal IHs should be individualized and consider all relevant risk factors, including prematurity.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
A Bibliometric Analysis of Alopecia Areata Literature over the Past 50 Years. A Case of Noonan Syndrome and Kyrle's Disease: Coincidence or Causality? COVID-19-associated Telogen Effluvium After Hospital Discharge: A Prospective Cohort Study. Is There a Need to Educate Patients with Atopic Dermatitis in Baseline Therapy? Leukomelanoderma Resembling Hyperpigmented Mycosis Fungoides.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1