管理出现罕见血型抗体 PP1Pk 的孕妇。

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY Women's health reports (New Rochelle, N.Y.) Pub Date : 2024-04-02 eCollection Date: 2024-01-01 DOI:10.1089/whr.2023.0120

Alexandra Bonmatí-Santané, Roberto Céspedes López, Jehimy Jean Alvarez Saltos, Jordi Calabia Martínez, Cristina Noboa Paez, Jordi Piedra Sánchez, Natalia Visa Figueredo, Anna Maroto González

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摘要

缺乏抗原 P、P1 和 Pk 的 p 表型孕妇会自发形成抗 P1Pk 抗体，其主要目标是胎盘。这些妇女的流产风险为 50%-70%，在怀孕后三个月达到 87%。这些疗法旨在降低妊娠早期的抗体滴度。由于世界上只有极少数相容的红细胞捐献者，她们也有发生溶血性输血反应的风险。在本研究中，我们介绍了一例通过自体献血和血浆置换术成功怀孕的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk.

Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.

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