C-反应蛋白不能预测青少年未来抑郁症的发病:一项纵向研究的初步发现

IF 1.5 4区 医学 Q2 PEDIATRICS Journal of child and adolescent psychopharmacology Pub Date : 2024-06-01 Epub Date: 2024-04-26 DOI:10.1089/cap.2023.0091
Joshua J Schwartz, Chloe Roske, Qi Liu, Russell H Tobe, Benjamin A Ely, Vilma Gabbay
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引用次数: 0

摘要

导言神经炎症过程与许多神经精神疾病的潜在神经生物学有着广泛的联系。C反应蛋白(CRP)是临床上常用的非特异性炎症指标,它的升高与成人抑郁症有关。在青少年中,我们的研究小组之前发现 CRP 与神经奖赏功能的改变有关,但与横截面评估的情绪和焦虑症状无关。我们假设,青少年与成人抑郁症中不同的 CRP 发现可能是由于神经炎症对精神障碍的影响是随着时间的推移逐渐累积的慢性化所致。在此,我们进行了一项纵向研究,以评估 CRP 水平是否可预测青少年抑郁症的未来发病或进展。研究方法研究对象为 53 名青少年(年龄 = 14.74 ± 1.92 岁,35 名女性),其中 40 名有精神症状,13 名为健康对照组。在基线期,参与者完成了半结构化诊断评估;焦虑、抑郁、失乐症和自杀严重程度的维度评估;以及量化 CRP 水平的血液检查。在 1.5 年后的纵向随访中再次进行临床评估。CRP水平与随访症状严重程度之间的斯皮尔曼相关性受体质量指数、年龄、性别和随访间隔的控制,并在双尾、Bonferroni调整后的P结果中被认为是显著的:经多重比较校正后,未发现基线 CRP 水平与随访症状严重程度之间存在任何关系。结论在这项初步分析中,CRP水平与青少年未来的精神症状并无明显关联。这可能表明 CRP 并非青少年抑郁和焦虑的有效生物标志物。不过,未来的纵向研究需要更大的样本量,并纳入更多的神经炎症指标。
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C-Reactive Protein Does Not Predict Future Depression Onset in Adolescents: Preliminary Findings from a Longitudinal Study.

Introduction: Neuroinflammatory processes have been extensively implicated in the underlying neurobiology of numerous neuropsychiatric disorders. Elevated C-reactive protein (CRP), an indicator of nonspecific inflammation commonly utilized in clinical practice, has been associated with depression in adults. In adolescents, our group previously found CRP to be associated with altered neural reward function but not with mood and anxiety symptoms assessed cross-sectionally. We hypothesized that the distinct CRP findings in adolescent versus adult depression may be due to chronicity, with neuroinflammatory effects on psychiatric disorders gradually accumulating over time. Here, we conducted a longitudinal study to evaluate if CRP levels predicted future onset or progression of depression in adolescents. Methods: Participants were 53 adolescents (age = 14.74 ± 1.92 years, 35 female), 40 with psychiatric symptoms and 13 healthy controls. At baseline, participants completed semistructured diagnostic evaluations; dimensional assessments for anxiety, depression, anhedonia, and suicidality severity; and bloodwork to quantify CRP levels. Clinical assessments were repeated at longitudinal follow-up after ∼1.5 years. Spearman's correlation between CRP levels and follow-up symptom severity were controlled for body mass index, age, sex, and follow-up interval and considered significant at the two-tailed, Bonferroni-adjusted p < 0.05 level. Results: After correction for multiple comparisons, no relationships were identified between baseline CRP levels and follow-up symptom severity. Conclusion: CRP levels were not significantly associated with future psychiatric symptoms in adolescents in this preliminary analysis. This may suggest that CRP is not a useful biomarker for adolescent depression and anxiety. However, future longitudinal studies with larger sample sizes and incorporating additional indicators of neuroinflammation are needed.

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来源期刊
CiteScore
3.60
自引率
5.30%
发文量
61
审稿时长
>12 weeks
期刊介绍: Journal of Child and Adolescent Psychopharmacology (JCAP) is the premier peer-reviewed journal covering the clinical aspects of treating this patient population with psychotropic medications including side effects and interactions, standard doses, and research on new and existing medications. The Journal includes information on related areas of medical sciences such as advances in developmental pharmacokinetics, developmental neuroscience, metabolism, nutrition, molecular genetics, and more. Journal of Child and Adolescent Psychopharmacology coverage includes: New drugs and treatment strategies including the use of psycho-stimulants, selective serotonin reuptake inhibitors, mood stabilizers, and atypical antipsychotics New developments in the diagnosis and treatment of ADHD, anxiety disorders, schizophrenia, autism spectrum disorders, bipolar disorder, eating disorders, along with other disorders Reports of common and rare Treatment Emergent Adverse Events (TEAEs) including: hyperprolactinemia, galactorrhea, weight gain/loss, metabolic syndrome, dyslipidemia, switching phenomena, sudden death, and the potential increase of suicide. Outcomes research.
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