白细胞介素 6 信号在射血分数保留和降低的心力衰竭中的作用

IF 0.5 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Kardiologiya Pub Date : 2024-03-31 DOI:10.18087/cardio.2024.3.n2534
E V Samoilova, A А Korotaeva, I V Zhirov, Yu O Aksenova, S N Nasonova, S N Tereschenko
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引用次数: 0

摘要

目的:鉴定慢性心力衰竭(CHF)患者的白细胞介素-6(IL-6)信号通路:IL-6作用的多样性是由于经典信号传导途径和跨信号传导途径的存在。研究纳入了164名因急性失代偿性心力衰竭(ADHF)住院的CHF患者,其中129人左室射血分数降低(HFrEF),35人射血分数保留(HFpEF)。测量了血液中IL-6、可溶性IL-6受体(sIL-6R)、可溶性转导蛋白gp130(sgp130)和高敏C反应蛋白(hsCRP)的浓度:HFpEF患者的IL-6浓度(6.15 [2.78, 10.65] pg/ml)和hsCRP浓度(11.27 [5.84, 24.40] mg/ml)低于HFrEF患者(分别为9.20 [4.70; 15.62] pg/ml和17.23 [8.70; 34.51 mg/ml])。相比之下,HFpEF 患者的 rIL-6R 浓度(59.06 [40.00; 75.85] 纳克/毫升)高于 HFrEF 患者(49.15 [38.20; 64.89] 纳克/毫升)。sgp130 的浓度没有明显差异。在HFrEF患者中,IL-6与hsCRP、IL-6与rIL-6R、IL-6与sgp130的浓度呈正相关,而在HFpEF患者中,只有IL-6与hsCRP之间存在相关性,且相关性似乎比HFrEF患者更强(分别为r=0.698;p<0.001和r=0.297;p<0.05):结论:经典的IL-6信号传导和跨信号传导在ADHF的HFrEF和HFpEF患者中有不同程度的表达。该研究结果补充了现有的有关 CHF 炎症发病机制的知识,可能有助于开发治疗该疾病的新方法和途径。
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Interleukin 6 Signalling in Heart Failure With Preserved and Reduced Ejection Fraction.

Aim: Identification of interleukin-6 (IL-6) signaling pathways in patients with chronic heart failure (CHF).

Material and methods: The diversity of IL-6 effects is due to the presence of classical signaling and trans-signaling pathways. The study included 164 patients with CHF hospitalized for acute decompensated heart failure (ADHF), of which 129 had reduced left ventricular ejection fraction (HFrEF), and 35 had preserved ejection fraction (HFpEF). Blood concentrations of IL-6, soluble IL-6 receptor (sIL-6R), soluble transducer protein gp130 (sgp130), and high-sensitivity C-reactive protein (hsCRP) were measured.

Results: Patients with HFpEF had lower concentrations of IL-6 (6.15 [2.78, 10.65] pg/ml) and hsCRP (11.27 [5.84, 24.40] mg/ml) than patients with HFrEF (9.20 [4.70; 15.62] pg/ml and 17.23 [8.70; 34.51 mg/ml], respectively). In contrast, concentrations of rIL-6R were higher in HFpEF (59.06 [40.00; 75.85] ng/ml) than in HFrEF (49.15 [38.20; 64.89] ng/ml). Concentrations of sgp130 were not significantly different. In patients with HFrEF, positive correlations were found between the concentrations of IL-6 and hsCRP, IL-6 and rIL-6R, and IL-6 and sgp130, while in patients with HFpEF, there was a correlation only between IL-6 and hsCRP, which appeared stronger than in patients with HFrEF (r=0.698; p<0.001 and r=0.297; p<0.05, respectively).

Conclusion: Classical IL-6 signaling and trans-signaling are expressed to different degrees in patients with HFrEF and HFpEF in ADHF. The results of the study supplement the existing knowledge about the pathogenesis of inflammation in CHF and may contribute to the development of new methods and approaches to the treatment of the disease.

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来源期刊
Kardiologiya
Kardiologiya 医学-心血管系统
CiteScore
1.70
自引率
20.00%
发文量
94
审稿时长
3-8 weeks
期刊介绍: “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.
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