矿物质皮质激素受体在癌症中的多方面作用

IF 2.7 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-05-05 DOI:10.1016/j.jsbmb.2024.106541

Tram B. Doan , J.Dinny Graham

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引用次数: 0

摘要

矿皮质激素受体（MR/NR3C2）是类固醇受体（SR）家族的成员，SR家族还包括雌激素受体（ER）、孕酮受体（PR）、雄激素受体（AR）和糖皮质激素受体（GR）。它们主要作为核受体调节基因表达。众所周知，其他类固醇激素受体在许多癌症的发病和进展过程中发挥着重要作用，但人们对 MR 在癌症生物学中的作用却知之甚少。本综述重点探讨 MR 在癌症中的潜在作用和作用机制的新见解。

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The multifaceted role of the mineralocorticoid receptor in cancers

The mineralocorticoid receptor (MR/NR3C2) is a member of the family of steroid receptors (SR) which also includes the estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and glucocorticoid receptor (GR). They function primarily as nuclear receptors to regulate gene expression. While the other steroid hormone receptors are known to play important roles in the pathogenesis and progression of many cancers, relatively little is understood about the role of MR in cancer biology. This review focuses on examining new insights into the potential roles and mechanisms of action of MR in cancers.

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来源期刊

Journal of Steroid Biochemistry and Molecular Biology 生物-内分泌学与代谢

CiteScore

8.60

自引率

2.40%

发文量

113

审稿时长

46 days

期刊介绍： The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids including vitamin D, lipids and their metabolomics. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics will be addressed in Special Issues managed by Guest Editors. Special Issues will contain both commissioned reviews and original research papers to provide comprehensive coverage of specific topics, and all submissions will undergo rigorous peer-review prior to publication.