[117 名腹主动脉瘤破裂患者的临床数据分析]。

X F Xu, L Kou, Y Chen, Z C Zeng, Q Li, Q Ye, J L Zhang
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摘要

目的研究接受手术修复的腹主动脉瘤(rAAA)破裂患者的围手术期临床特征和预后。方法回顾性分析2005年8月至2020年11月期间首都医科大学附属北京安贞医院外科重症监护室收治的接受手术修补的rAAA患者的临床资料,包括一般临床特征、手术方式、术中情况、术后并发症和死亡率。结果117例rAAA患者的中位年龄为68(62,77)岁,其中男性93例(79.5%),女性24例(20.5%)。主要临床表现为腹痛(115 人,占 98.3%)。其中,65 名(55.6%)患者接受了血管内动脉瘤修补术(EVAR),52 名(44.4%)患者接受了开放手术修补术(OSR)。常见的术后并发症包括急性胃肠道功能障碍(n=116,99.1%)、休克(n=89,76.1%)、急性呼吸窘迫综合征(n=85,72.6%)、胰腺损伤(n=56,47.9%)、凝血功能障碍(n=55,47.0%)、弥散性血管内凝血(n=46,39.3%)、急性肾损伤(n=39,33.3%)、感染/败血症(n=28,23.9%)、消化道出血(n=17,14.5%)和腹腔间隔综合征(n=12,10.3%)。总体术后院内死亡率为10.3%(12/117)。术前使用血管加压药和肌注药、腹膜后血肿以及术后腹腔室综合征、胃肠道出血、急性肾损伤和弥漫性血管内凝血显著增加了死亡率[分别为5/11、6/24、5/16、6/12、6/17、23.1%(9/39)、19.6%(9/46)]。结论在EVAR时代,rAAA患者的术后死亡率仍然很高,尤其是术前存在休克和腹膜后血肿、术后存在腹腔室综合征、凝血功能障碍和急性肾损伤的患者。有必要加强对这些患者的围手术期监测和管理,以降低死亡率。
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[Clinical data analysis of 117 patients with ruptured abdominal aortic aneurysm].

Objective: To examine the perioperative clinical features and prognosis of patients with ruptured abdominal aortic aneurysms (rAAA) who received surgical repair. Methods: The clinical data of rAAA patients who underwent surgical repair and were admitted to the Surgical Intensive Care Unit of Beijing Anzhen Hospital, Capital Medical University from August 2005 to November 2020 were retrospectively analyzed, including the general clinical features, surgical mode, intraoperative conditions, postoperative complications, and fatality rate. Results: There were 117 patients with rAAA, with a median age of 68 (62,77) years, including 93 men (79.5%) and 24 women (20.5%). The main clinical manifestation was abdominal pain (n=115, 98.3%). Among them, 65 (55.6%) patients underwent endovascular aneurysm repair (EVAR), while 52 (44.4%) underwent open surgical repair (OSR). The common postoperative complications include acute gastrointestinal dysfunction (n=116, 99.1%), shock (n=89, 76.1%), acute respiratory distress syndrome (n=85, 72.6%), pancreatic injury (n=56, 47.9%), coagulation dysfunction (n=55, 47.0%), disseminated intravascular coagulation (n=46, 39.3%), acute kidney injury (n=39, 33.3%), infection/sepsis (n=28, 23.9%), gastrointestinal bleeding (n=17, 14.5%), and abdominal compartment syndrome (n=12, 10.3%). The overall postoperative in-hospital fatality rate was 10.3% (12/117). Preoperative use of vasopressors and inotropes, retroperitoneal hematoma, and postoperative abdominal compartment syndrome, gastrointestinal hemorrhage, acute kidney injury, and diffuse intravascular coagulation significantly increased the fatality rate [5/11, 6/24, 5/16, 6/12, 6/17, 23.1%(9/39), 19.6%(9/46), respectively]. Conclusion: The postoperative mortality of rAAA patients is still high in the era of EVAR, especially in patients with preoperative existence of shock and retroperitoneal hematoma, and with postoperative abdominal compartment syndrome, coagulation dysfunction, and acute kidney injury. It is necessary to strengthen perioperative monitoring and management of these patients to reduce the fatality rate.

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