Xianghang Chen, Beini Wang, Yongxiu Zhou, Xuejuan Wu, Anyu Du, Abdullah Al Mamun, Yitie Xu, Shuangshuang Wang, Chang Jiang, Ling Xie, Kailiang Zhou, Siwang Hu, Jian Xiao
{"title":"含 bFGF 的聚(白桦脂酸)纳米颗粒可改善脊髓损伤后的功能恢复(Adv.)","authors":"Xianghang Chen, Beini Wang, Yongxiu Zhou, Xuejuan Wu, Anyu Du, Abdullah Al Mamun, Yitie Xu, Shuangshuang Wang, Chang Jiang, Ling Xie, Kailiang Zhou, Siwang Hu, Jian Xiao","doi":"10.1002/adhm.202470080","DOIUrl":null,"url":null,"abstract":"<p><b>Nanoparticle</b></p><p>In article 2303462, Kailiang Zhou, Siwang Hu, Jian Xiao and co-workers synthesize betulinic acid (BA) into polybetulinic acid (PBA) to serve as a drug carrier for bFGF and forms PBA-bFGF nanoparticles (PBA-bFGF NPs). After uptake by cells, PBA-bFGF NPs are degraded by enzymes in the cell, and the generated BA and released bFGF participate in therapy.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":null,"pages":null},"PeriodicalIF":10.0000,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470080","citationCount":"0","resultStr":"{\"title\":\"Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury (Adv. Healthcare Mater. 12/2024)\",\"authors\":\"Xianghang Chen, Beini Wang, Yongxiu Zhou, Xuejuan Wu, Anyu Du, Abdullah Al Mamun, Yitie Xu, Shuangshuang Wang, Chang Jiang, Ling Xie, Kailiang Zhou, Siwang Hu, Jian Xiao\",\"doi\":\"10.1002/adhm.202470080\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Nanoparticle</b></p><p>In article 2303462, Kailiang Zhou, Siwang Hu, Jian Xiao and co-workers synthesize betulinic acid (BA) into polybetulinic acid (PBA) to serve as a drug carrier for bFGF and forms PBA-bFGF nanoparticles (PBA-bFGF NPs). After uptake by cells, PBA-bFGF NPs are degraded by enzymes in the cell, and the generated BA and released bFGF participate in therapy.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":113,\"journal\":{\"name\":\"Advanced Healthcare Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":10.0000,\"publicationDate\":\"2024-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470080\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Healthcare Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202470080\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202470080","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
摘要
纳米颗粒在文章2303462中,周开良、胡思望、肖健及其合作者将白桦脂酸(BA)合成为聚白桦脂酸(PBA),作为bFGF的药物载体,形成PBA-bFGF纳米颗粒(PBA-bFGF NPs)。PBA-bFGF NPs 被细胞吸收后,会被细胞中的酶降解,生成的 BA 和释放的 bFGF 参与治疗。
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury (Adv. Healthcare Mater. 12/2024)
Nanoparticle
In article 2303462, Kailiang Zhou, Siwang Hu, Jian Xiao and co-workers synthesize betulinic acid (BA) into polybetulinic acid (PBA) to serve as a drug carrier for bFGF and forms PBA-bFGF nanoparticles (PBA-bFGF NPs). After uptake by cells, PBA-bFGF NPs are degraded by enzymes in the cell, and the generated BA and released bFGF participate in therapy.
期刊介绍:
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.