紫杉叶素、紫杉叶素与甘草酸的共轭物以及柚皮苷对中性粒细胞功能活性的影响

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-07 DOI:10.1134/S0006350923050275
V. S. Shubina, M. I. Kobyakova, Yu. V. Shatalin
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摘要

摘要 这项工作的目的是研究紫杉叶素、紫杉叶素与乙醛酸的共轭物以及柚皮苷对中性粒细胞吞噬乳胶珠以及这些细胞的粘附性的影响。研究表明,紫杉叶素不影响中性粒细胞的吞噬活性和粘附性。Taxifolin 与乙醛酸的共轭物能显著抑制中性粒细胞的吞噬活性。该共轭物还能明显增强这些细胞的粘附性。柚皮苷可降低中性粒细胞的吞噬活性,但降低程度低于共轭物。柚皮苷还能抑制中性粒细胞的粘附。获得的数据表明,多酚类物质可以影响中性粒细胞的功能活性;这种作用可以在调节炎症过程中发挥重要作用,特别是当中性粒细胞的长期激活导致人体自身细胞和组织受损时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Effect of Taxifolin, a Conjugate of Taxifolin with Glyoxylic Acid, and Naringenin on the Functional Activity of Neutrophils

The aim of this work was to study the effect of taxifolin, a conjugate of taxifolin with glyoxalic acid, and naringenin on the phagocytosis of latex beads by neutrophils and the adhesive properties of these cells. It has been shown that taxifolin did not affect the phagocytic activity and adhesive properties of neutrophils. The conjugate of taxifolin with glyoxylic acid significantly inhibited the phagocytic activity of neutrophils. The conjugate also significantly enhanced the adhesion of these cells. Naringenin reduced the phagocytic activity of neutrophils, however, to a lesser extent than the conjugate. Naringenin also inhibited the adhesion of neutrophils. The data obtained indicate that polyphenols can affect the functional activity of neutrophils; this effect can play an important role in modulating the inflammatory process, in particular when prolonged activation of neutrophils leads to damage of the body’s own cells and tissues.

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来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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