紫杉叶素、紫杉叶素与甘草酸的共轭物以及柚皮苷对中性粒细胞功能活性的影响

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-07 DOI:10.1134/S0006350923050275
V. S. Shubina, M. I. Kobyakova, Yu. V. Shatalin
{"title":"紫杉叶素、紫杉叶素与甘草酸的共轭物以及柚皮苷对中性粒细胞功能活性的影响","authors":"V. S. Shubina,&nbsp;M. I. Kobyakova,&nbsp;Yu. V. Shatalin","doi":"10.1134/S0006350923050275","DOIUrl":null,"url":null,"abstract":"<p>The aim of this work was to study the effect of taxifolin, a conjugate of taxifolin with glyoxalic acid, and naringenin on the phagocytosis of latex beads by neutrophils and the adhesive properties of these cells. It has been shown that taxifolin did not affect the phagocytic activity and adhesive properties of neutrophils. The conjugate of taxifolin with glyoxylic acid significantly inhibited the phagocytic activity of neutrophils. The conjugate also significantly enhanced the adhesion of these cells. Naringenin reduced the phagocytic activity of neutrophils, however, to a lesser extent than the conjugate. Naringenin also inhibited the adhesion of neutrophils. The data obtained indicate that polyphenols can affect the functional activity of neutrophils; this effect can play an important role in modulating the inflammatory process, in particular when prolonged activation of neutrophils leads to damage of the body’s own cells and tissues.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":null,"pages":null},"PeriodicalIF":4.0330,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effect of Taxifolin, a Conjugate of Taxifolin with Glyoxylic Acid, and Naringenin on the Functional Activity of Neutrophils\",\"authors\":\"V. S. Shubina,&nbsp;M. I. Kobyakova,&nbsp;Yu. V. Shatalin\",\"doi\":\"10.1134/S0006350923050275\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The aim of this work was to study the effect of taxifolin, a conjugate of taxifolin with glyoxalic acid, and naringenin on the phagocytosis of latex beads by neutrophils and the adhesive properties of these cells. It has been shown that taxifolin did not affect the phagocytic activity and adhesive properties of neutrophils. The conjugate of taxifolin with glyoxylic acid significantly inhibited the phagocytic activity of neutrophils. The conjugate also significantly enhanced the adhesion of these cells. Naringenin reduced the phagocytic activity of neutrophils, however, to a lesser extent than the conjugate. Naringenin also inhibited the adhesion of neutrophils. The data obtained indicate that polyphenols can affect the functional activity of neutrophils; this effect can play an important role in modulating the inflammatory process, in particular when prolonged activation of neutrophils leads to damage of the body’s own cells and tissues.</p>\",\"PeriodicalId\":493,\"journal\":{\"name\":\"Biophysics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0330,\"publicationDate\":\"2024-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biophysics\",\"FirstCategoryId\":\"4\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S0006350923050275\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1134/S0006350923050275","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0

摘要

摘要 这项工作的目的是研究紫杉叶素、紫杉叶素与乙醛酸的共轭物以及柚皮苷对中性粒细胞吞噬乳胶珠以及这些细胞的粘附性的影响。研究表明,紫杉叶素不影响中性粒细胞的吞噬活性和粘附性。Taxifolin 与乙醛酸的共轭物能显著抑制中性粒细胞的吞噬活性。该共轭物还能明显增强这些细胞的粘附性。柚皮苷可降低中性粒细胞的吞噬活性,但降低程度低于共轭物。柚皮苷还能抑制中性粒细胞的粘附。获得的数据表明,多酚类物质可以影响中性粒细胞的功能活性;这种作用可以在调节炎症过程中发挥重要作用,特别是当中性粒细胞的长期激活导致人体自身细胞和组织受损时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The Effect of Taxifolin, a Conjugate of Taxifolin with Glyoxylic Acid, and Naringenin on the Functional Activity of Neutrophils

The aim of this work was to study the effect of taxifolin, a conjugate of taxifolin with glyoxalic acid, and naringenin on the phagocytosis of latex beads by neutrophils and the adhesive properties of these cells. It has been shown that taxifolin did not affect the phagocytic activity and adhesive properties of neutrophils. The conjugate of taxifolin with glyoxylic acid significantly inhibited the phagocytic activity of neutrophils. The conjugate also significantly enhanced the adhesion of these cells. Naringenin reduced the phagocytic activity of neutrophils, however, to a lesser extent than the conjugate. Naringenin also inhibited the adhesion of neutrophils. The data obtained indicate that polyphenols can affect the functional activity of neutrophils; this effect can play an important role in modulating the inflammatory process, in particular when prolonged activation of neutrophils leads to damage of the body’s own cells and tissues.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
期刊最新文献
Reductive Nitrosylation of Hemoglobin and Myoglobin and its Antioxidant Effect Supercomputer Simulation of Intramolecular Oscillations of Glycine, Diphenylalanine, and Tryptophan in an Electric Field of the Terahertz and Infrared Ranges On the Role of Priming in the Development of Modern Rehabilitation Technologies The Inhibitory Effect of Oxibiol on the Process of Protein Modification by Water-Soluble Products of Photo-Oxidative Destruction of Bisretinoid A2E An X-Ray Diffraction Study of Lipid Films with ICHPHAN
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1