凝结因子对纤维蛋白吸附膜特性的影响

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-07 DOI:10.1134/S1061933X24600052
O. Yu. Milyaeva, A. R. Rafikova
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引用次数: 0

摘要

摘要切口和伤口处纤维蛋白膜的形成是一个复杂的生化过程,其主要成分是纤维蛋白原和凝血酶以及其他酶和蛋白质。从含有因子 VIII、XIIIa、von Willebrand 因子和纤维粘连蛋白的溶液中获得的吸附膜的动态表面特性,与从仅含有纤维蛋白原和凝血酶的溶液中获得的纤维蛋白原吸附膜和纤维蛋白膜不同。它们的动态表面弹性超过纤维蛋白原的相应值(分别为 80 和 55 mN/m),但似乎低于纯成分制备的纤维蛋白的值(115 mN/m)。从止血胶水中获得的吸附膜的表面压力(27 mN/m)超过了上述两种体系的表面压力(14 mN/m)。从布儒斯特角显微镜和扫描电子显微镜的数据可以看出,所产生薄膜的形态发生了显著变化,这就是所观察到的效果的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Impact of Coagulation Factors on the Properties of Fibrin Adsorption Films

The formation of a fibrin film at the sites of cuts and wounds is a complex biochemical process that involves fibrinogen and thrombin as the main components, as well as other enzymes and proteins. Dynamic surface properties of adsorption films obtained from the solution, which contains factors VIII, XIIIa, von Willebrand factor and fibronectin, differ from the fibrinogen adsorption films and fibrin films obtained from a solution containing only fibrinogen and thrombin. Their dynamic surface elasticities exceed the corresponding values for fibrinogen (80 and 55 mN/m, respectively); however, they appear to be lower than value for fibrin prepared from pure components (115 mN/m). The surface pressures achieved for the adsorption films obtained from hemostatic glue (27 mN/m) exceed those for both aforementioned systems (14 mN/m). As follows from the Brewster angle microscopy and scanning electron microscopy data, significant changes in the morphology of the resulting films are responsible for the observed effect.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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