{"title":"基于 JL-TFET 的高灵敏度生物传感器的仿真与建模,用于无标记生物分子检测","authors":"Pratikhya Raut, Deepak Kumar Panda, Umakanta Nanda, Chih-Chieh Hsu","doi":"10.1007/s00542-024-05638-7","DOIUrl":null,"url":null,"abstract":"<p>A biosensor employing a junctionless TFET (JL-TEFT) to identify different protein molecules is modelled and investigated in this paper. The JLTFET is chosen for designing the biosensor because of its superiority over TFET and JLFET. The biomolecules can be captured in this type of devices by creating cavities across the gate. Various output parameters of label free biosensing with respect to various dielectric constants was studied using TCAD simulator. This article further portrays current and voltage sensitivity. This paper also investigates the fill factor impact of size of biomolecules and cavity positioning on the performance of biosensor. The dielectric modulation method for identifying a range of proteins and amino acids is being investigated through simulations. The sensitivity of JLTFET-based biosensors was found to be 10<sup>13</sup>. The novelties in this manuscript is that for the first time, an analytical mathematical model of a triple material gate asymmetrical hetero-dielectric JLTFET biosensor has been derived here. The developed model is not having any empirical parameter. Hence the proposed model is faster. Besides exhibiting increased sensitivity when compared to previous FET and TFET-based biosensors, this device also shows its suitability for low-power applications, hence providing a multitude of avenues for future exploration.</p>","PeriodicalId":18544,"journal":{"name":"Microsystem Technologies","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Simulation and modeling of high-sensitive JL-TFET based biosensor for label free detection of biomolecules\",\"authors\":\"Pratikhya Raut, Deepak Kumar Panda, Umakanta Nanda, Chih-Chieh Hsu\",\"doi\":\"10.1007/s00542-024-05638-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A biosensor employing a junctionless TFET (JL-TEFT) to identify different protein molecules is modelled and investigated in this paper. The JLTFET is chosen for designing the biosensor because of its superiority over TFET and JLFET. The biomolecules can be captured in this type of devices by creating cavities across the gate. Various output parameters of label free biosensing with respect to various dielectric constants was studied using TCAD simulator. This article further portrays current and voltage sensitivity. This paper also investigates the fill factor impact of size of biomolecules and cavity positioning on the performance of biosensor. The dielectric modulation method for identifying a range of proteins and amino acids is being investigated through simulations. The sensitivity of JLTFET-based biosensors was found to be 10<sup>13</sup>. The novelties in this manuscript is that for the first time, an analytical mathematical model of a triple material gate asymmetrical hetero-dielectric JLTFET biosensor has been derived here. The developed model is not having any empirical parameter. Hence the proposed model is faster. Besides exhibiting increased sensitivity when compared to previous FET and TFET-based biosensors, this device also shows its suitability for low-power applications, hence providing a multitude of avenues for future exploration.</p>\",\"PeriodicalId\":18544,\"journal\":{\"name\":\"Microsystem Technologies\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microsystem Technologies\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00542-024-05638-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microsystem Technologies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00542-024-05638-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Simulation and modeling of high-sensitive JL-TFET based biosensor for label free detection of biomolecules
A biosensor employing a junctionless TFET (JL-TEFT) to identify different protein molecules is modelled and investigated in this paper. The JLTFET is chosen for designing the biosensor because of its superiority over TFET and JLFET. The biomolecules can be captured in this type of devices by creating cavities across the gate. Various output parameters of label free biosensing with respect to various dielectric constants was studied using TCAD simulator. This article further portrays current and voltage sensitivity. This paper also investigates the fill factor impact of size of biomolecules and cavity positioning on the performance of biosensor. The dielectric modulation method for identifying a range of proteins and amino acids is being investigated through simulations. The sensitivity of JLTFET-based biosensors was found to be 1013. The novelties in this manuscript is that for the first time, an analytical mathematical model of a triple material gate asymmetrical hetero-dielectric JLTFET biosensor has been derived here. The developed model is not having any empirical parameter. Hence the proposed model is faster. Besides exhibiting increased sensitivity when compared to previous FET and TFET-based biosensors, this device also shows its suitability for low-power applications, hence providing a multitude of avenues for future exploration.