Sarah E Paul, David A A Baranger, Emma C Johnson, Joshua J Jackson, Aaron J Gorelik, Alex P Miller, Alexander S Hatoum, Wesley K Thompson, Michael Strube, Danielle M Dick, Chella Kamarajan, John R Kramer, Martin H Plawecki, Grace Chan, Andrey P Anokhin, David B Chorlian, Sivan Kinreich, Jacquelyn L Meyers, Bernice Porjesz, Howard J Edenberg, Arpana Agrawal, Kathleen K Bucholz, Ryan Bogdan
{"title":"酒精里程碑与内化、外化和执行功能:纵向和多基因得分关联。","authors":"Sarah E Paul, David A A Baranger, Emma C Johnson, Joshua J Jackson, Aaron J Gorelik, Alex P Miller, Alexander S Hatoum, Wesley K Thompson, Michael Strube, Danielle M Dick, Chella Kamarajan, John R Kramer, Martin H Plawecki, Grace Chan, Andrey P Anokhin, David B Chorlian, Sivan Kinreich, Jacquelyn L Meyers, Bernice Porjesz, Howard J Edenberg, Arpana Agrawal, Kathleen K Bucholz, Ryan Bogdan","doi":"10.1017/S003329172400076X","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.</p><p><strong>Methods: </strong>Data came from the Collaborative Study on the Genetics of Alcoholism (<i>n</i> = 3681; ages 11-36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones.</p><p><strong>Results: </strong>Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). Problematic alcohol use PGS increased hazards for suicidal ideation (HR = 1.20).</p><p><strong>Conclusions: </strong>Behavioral markers of addiction vulnerability precede and follow alcohol transitions, highlighting dynamic, bidirectional relationships between behavior and emerging addiction.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":5.9000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.\",\"authors\":\"Sarah E Paul, David A A Baranger, Emma C Johnson, Joshua J Jackson, Aaron J Gorelik, Alex P Miller, Alexander S Hatoum, Wesley K Thompson, Michael Strube, Danielle M Dick, Chella Kamarajan, John R Kramer, Martin H Plawecki, Grace Chan, Andrey P Anokhin, David B Chorlian, Sivan Kinreich, Jacquelyn L Meyers, Bernice Porjesz, Howard J Edenberg, Arpana Agrawal, Kathleen K Bucholz, Ryan Bogdan\",\"doi\":\"10.1017/S003329172400076X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.</p><p><strong>Methods: </strong>Data came from the Collaborative Study on the Genetics of Alcoholism (<i>n</i> = 3681; ages 11-36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones.</p><p><strong>Results: </strong>Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). 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引用次数: 0
摘要
背景:尽管酗酒与行为表型(如冲动、消极情绪、执行功能[EF])之间的联系已得到证实,但这些联系的方向性、酗酒阶段的特异性以及共同遗传责任的程度仍不清楚。我们估算了酗酒里程碑、行为表型和遗传风险指数之间的纵向关联:数据来自酗酒遗传学合作研究(n = 3681;年龄 11-36 岁)。酒精过渡(第一次:饮酒、醉酒、酒精使用障碍[AUD]症状、酒精使用障碍诊断)、内化和外化表型来自酗酒遗传学半结构化评估(Semi-Structured Assessment for the Genetics of Alcoholism)。EF通过伦敦塔和视觉跨度任务进行测量。计算了酒精相关表型和行为表型的多基因分数(PGS)。Cox 模型估计了 PGS、行为和酗酒里程碑之间的关联:结果:外化表型(如行为障碍症状)与未来开始酗酒和酗酒问题有关(危险比(HR)⩾1.16)。内化表型(如社交焦虑)与从首次酗酒发展到严重 AUD 的危险比相关(HR⩾1.55)。开始饮酒和 AUD 与日后抑郁症状和自杀意念的危险增加有关(HR⩾1.38),开始饮酒与日后行为症状的危险增加有关(HR = 1.60)。EF 与酒精过渡无关。每周饮酒量 PGS 与酒精过渡的危险性增加有关(HR⩾1.06)。有问题的饮酒 PGS 增加了自杀倾向的危险性(HR = 1.20):成瘾脆弱性的行为标记在酒精过渡之前和之后出现,突显了行为和新出现的成瘾之间的动态双向关系。
Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.
Background: Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.
Methods: Data came from the Collaborative Study on the Genetics of Alcoholism (n = 3681; ages 11-36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones.
Results: Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). Problematic alcohol use PGS increased hazards for suicidal ideation (HR = 1.20).
Conclusions: Behavioral markers of addiction vulnerability precede and follow alcohol transitions, highlighting dynamic, bidirectional relationships between behavior and emerging addiction.
期刊介绍:
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.