胃癌患者基础代谢率与临床预后的相关性:一项回顾性研究

IF 2.1 4区 医学 Q2 SURGERY Journal of Investigative Surgery Pub Date : 2024-12-01 Epub Date: 2024-05-09 DOI:10.1080/08941939.2024.2350358
Yun-Shi Huang, Xiu-Ya Zeng, Wei-Sheng Chen, Wen-Tao Cai
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引用次数: 0

摘要

目的:高代谢与癌症患者的临床预后有关。本研究旨在探讨基础代谢率(BMR)与胃癌患者术后临床预后之间的关系:我们收集了本中心从 2014 年 6 月至 2018 年 12 月收治的 958 例胃癌患者的数据。通过X-tile图得出BMR的最佳临界值(BMR≤1149千卡/天)。然后进行逻辑回归分析和 Cox 回归分析,以评估临床结局的相关影响因素。最后,利用 R 软件构建了提名图:共有 213 名患者被定义为基础代谢率较低(LBMR)。单变量和多变量分析表明,基础代谢率较低的胃癌患者更容易出现术后并发症,长期总生存率(OS)也较低。已建立的提名图在评估胃癌根治术后患者的OS风险方面具有良好的预测能力(c指数为0.764):总体而言,胃癌患者入院时的低密度脂蛋白胆固醇血症与术后并发症的发生有关,而且这一人群的长期生存率较低。因此,应在手术前更加关注有此风险因素的患者的围手术期管理。
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Correlation Between Basal Metabolic Rate and Clinical Outcomes in Gastric Cancer Patients: A Retrospective Study.

Objectives: Hypermetabolism is associated with clinical prognosis of cancer patients. The aim of this study was to explore the association between basal metabolic rate (BMR) and postoperative clinical outcomes in gastric cancer patients.

Methods: We collected data of 958 gastric cancer patients admitted at our center from June 2014 to December 2018. The optimal cutoff value of BMR (BMR ≤1149 kcal/day) was obtained using the X-tile plot. Logistic and Cox regression analyses were then performed to evaluate the relevant influencing factors of clinical outcomes. Finally, R software was utilized to construct the nomogram.

Results: A total of 213 patients were defined as having a lower basal metabolic rate (LBMR). Univariate and multivariate analyses showed that gastric cancer patients with LBMR were more prone to postoperative complications and had poor long-term overall survival (OS). The established nomogram had good predictive power to assess the risk of OS in gastric cancer patients after radical gastrectomy (c-index was 0.764).

Conclusions: Overall, LBMR on admission is associated with the occurrence of postoperative complications in gastric cancer patients, and this population has a poorer long-term survival. Therefore, there should be more focus on the perioperative management of patients with this risk factor before surgery.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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