光子与碳离子辐照对大鼠颈脊髓的影响--连续 T2 和弥散加权磁共振成像研究

IF 2.5 3区 医学 Q2 BIOLOGY Radiation research Pub Date : 2024-07-01 DOI:10.1667/RADE-23-00151.1
Thomas Welzel, Maria Saager, Peter Peschke, Jürgen Debus, Christian P Karger
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引用次数: 0

摘要

碳离子辐照越来越多地用于对辐射敏感的脊髓附近的颅底和脊柱。为了更好地描述颈部脊髓的体内辐射反应,我们使用磁共振成像(MRI)弥散测量法测量了大鼠高剂量区的辐射变化,并与传统的光子辐照进行了比较。在这项纵向核磁共振成像研究中,我们检测了 16 只雌性 Sprague-Dawley 大鼠在接受高剂量光子(8 只)或碳离子(12C)照射(8 只)后以及 6 只假照射大鼠的颈脊髓灰质(GM),直到发生脊髓病变。研究人员对颈脊髓基因组弥散模式的差异进行了检测,直到研究终点--双前肢发生二级瘫痪为止。在两种辐射技术中,观察到的磁共振形态病理学发生顺序相同--从水肿形成到血脊髓屏障(BSCB)破坏,再到双前肢Ⅱ级瘫痪。然而,碳离子辐照显示平均表观扩散系数(ADC;P = 0.031)随着基因组中血脊髓屏障的破坏而显著增加。作为晚期辐射反应,瘫痪程度达到 II 级的动物在接受碳离子照射后,平均表观弥散系数(ADC)有非常明显的增加(P = 0.0001)。此时,与光子辐照相比,12C辐照后基因组的平均 ADC 值有升高的趋势(P = 0.059)。这些研究结果表明,与光子辐照相比,碳离子辐照的线性能量转移(LET)值更高,因此对大鼠颈脊髓GM的结构损伤更大。
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Effects of Photon versus Carbon-Ion Irradiation in the Rat Cervical Spinal Cord - a Serial T2 and Diffusion-weighted Magnetic Resonance Imaging Study.

Carbon-ion irradiation is increasingly used at the skull base and spine near the radiation-sensitive spinal cord. To better characterize the in vivo radiation response of the cervical spinal cord, radiogenic changes in the high-dose area were measured in rats using magnetic resonance imaging (MRI) diffusion measurements in comparison to conventional photon irradiations. In this longitudinal MRI study, we examined the gray matter (GM) of the cervical spinal cord in 16 female Sprague-Dawley rats after high-dose photon (n = 8) or carbon-ion (12C) irradiation (n = 8) and in 6 sham-exposed rats until myelopathy occurred. The differences in the diffusion pattern of the GM of the cervical spinal cord were examined until the endpoint of the study, occurrence of paresis grade II of both forelimbs was reached. In both radiation techniques, the same order of the occurrence of MR-morphological pathologies was observed - from edema formation to a blood spinal cord barrier (BSCB) disruption to paresis grade II of both forelimbs. However, carbon-ion irradiation showed a significant increase of the mean apparent diffusion coefficient (ADC; P = 0.031) with development of a BSCB disruption in the GM. Animals with paresis grade II as a late radiation response had a highly significant increase in mean ADC (P = 0.0001) after carbon-ion irradiation. At this time, a tendency was observed for higher mean ADC values in the GM after 12C irradiation as compared to photon irradiation (P = 0.059). These findings demonstrated that carbon-ion irradiation leads to greater structural damage to the GM of the rat cervical spinal cord than photon irradiation due to its higher linear energy transfer (LET) value.

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来源期刊
Radiation research
Radiation research 医学-核医学
CiteScore
5.10
自引率
8.80%
发文量
179
审稿时长
1 months
期刊介绍: Radiation Research publishes original articles dealing with radiation effects and related subjects in the areas of physics, chemistry, biology and medicine, including epidemiology and translational research. The term radiation is used in its broadest sense and includes specifically ionizing radiation and ultraviolet, visible and infrared light as well as microwaves, ultrasound and heat. Effects may be physical, chemical or biological. Related subjects include (but are not limited to) dosimetry methods and instrumentation, isotope techniques and studies with chemical agents contributing to the understanding of radiation effects.
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