比较无机纳米载体和有机纳米载体在不同类型肿瘤中的被动靶向给药。

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-05-09 DOI:10.1016/j.nano.2024.102753
Alisa S. Postovalova M.Sc , Yulia A. Tishchenko B.Sc , Maria S. Istomina M.Sc , Timofey E. Karpov M.Sc , Sergei A. Shipilovskikh Ph.D , Daria Akhmetova M.Sc , Anna Rogova M.Sc , Nina V. Gavrilova M.Sc , Alexander S. Timin Ph.D
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引用次数: 0

摘要

在这项研究中,我们考虑了四种类型的纳米粒子(NPs):聚乳酸(PLA)、金(Au)、碳酸钙(CaCO3)和二氧化硅(SiO2),它们具有相似的尺寸(TEM:50-110 nm,DLS:110-140 nm),研究了它们在三种不同肿瘤(结肠癌(CT26)、黑色素瘤(B16-F10)和乳腺癌(4T1))中的被动积累。我们的研究结果表明,每种肿瘤模型都表现出不同的 NPs 积累情况,具体顺序如下:CT26 > B16-F10 > 4T1。与 CaCO3 和 SiO2 NPs 相比,Au 和 PLA NPs 在 CT26 肿瘤中的输送效率更高。与其他 NPs 相比,Au NPs 在 B16-F10 细胞中的蓄积量最高。这些结果通过 SPECT、体内外荧光生物成像、直接辐射测量和组织学分析得到了验证。因此,这项工作为 NPs 的被动肿瘤靶向提供了新的知识,可用于开发新的肿瘤递送策略。
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Comparison of passive targeted delivery of inorganic and organic nanocarriers among different types of tumors

In this study, we have considered four types of nanoparticles (NPs): polylactic acid (PLA), gold (Au), calcium carbonate (CaCO3), and silica (SiO2) with similar sizes (TEM: 50–110 nm and DLS: 110–140 nm) to examine their passive accumulation in three different tumors: colon (CT26), melanoma (B16-F10), and breast (4T1) cancers. Our results demonstrate that each tumor model showed a different accumulation of NPs, in the following order: CT26 > B16-F10 > 4T1. The Au and PLA NPs were evidently characterized by a higher delivery efficiency in case of CT26 tumors compared to CaCO3 and SiO2 NPs. The Au NPs demonstrated the highest accumulation in B16-F10 cells compared to other NPs. These results were verified using SPECT, ex vivo fluorescence bioimaging, direct radiometry and histological analysis. Thus, this work contributes to new knowledge in passive tumor targeting of NPs and can be used for the development of new strategies for delivery of bioactive compounds.

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来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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