用于三维生物打印的高伸展性藻酸盐/甲基纤维素水凝胶:增强结构完整性的光聚合方法

IF 5.4 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY GIANT Pub Date : 2024-05-07 DOI:10.1016/j.giant.2024.100280
Sorour Sadeghzade , Jinrui Cao , Rui Yang , Yuanlong Li , Yanping Li , Dingcong Zhang , Jingyi Liu , Ziyue Yu , Liang Fang , Hongyan Yuan
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引用次数: 0

摘要

近年来,基于藻酸盐(Alg)的三维水凝胶取得了长足的进步,为生物医学和再生医学带来了变革潜力。然而,为了打印复杂的三维结构,藻酸盐的粘度需要进一步提高。调整打印性能的尝试通常采用甲基纤维素(MC)等流变改性剂,但对于更广泛的生物医学应用而言,这些改性剂仍然缺乏机械完整性。我们的研究试图对 Alg/MC 进行化学改性,通过加入丙烯酸酯类单体来创建一种可光聚合的水凝胶,这将增强基础水凝胶的固化能力,从而提高 Alg/MC 的机械性能,如拉伸性和形状恢复稳定性。全面的机械评估揭示了其卓越的拉伸性能,在达到断裂点之前,比强度基准达到了 44.72 kPa/(g.cm-3)。与不含丙烯酸酯单体的样品相比,该性能大幅提高了 250%。生物医学评估证实了这种水凝胶的巨大潜力,尤其是在 MG-63 细胞系中的应用,突出了它在组织工程等高级应用中的适用性。
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Highly stretchable alginate/methylcellulose hydrogels for 3D bio-printing: photopolymerization approach enhancing structural integrity

In recent years, 3D hydrogels based on alginate (Alg) have undergone substantial advancements, holding transformative potential for biomedicine and regenerative medicine. Nevertheless, the viscosity of Alg needs to be further increased, in order to print complex 3D structures. Attempts to adjust printability often employ rheological modifiers like methylcellulose (MC), but these still lack mechanical integrity for broader biomedical applications. Our study sought to chemically modify Alg/MC to create a photopolymerizable hydrogel by incorporating acrylate-based monomers, which would enhance the curing ability of the base hydrogel, leading to better mechanical properties of Alg/MC, such as stretchability and stability with shape recovery. Comprehensive mechanical assessments unveiled remarkable tensile properties, achieving a notable specific strength benchmark of 44.72 kPa/(g.cm-3) before reaching the point of fracture. This represents a substantial 250 % improvement compared to samples lacking the acrylate monomer. Biomedical assessments confirmed the hydrogel's promising potential, especially with the MG-63 cell line, underscoring its suitability for advanced applications like tissue engineering.

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来源期刊
GIANT
GIANT Multiple-
CiteScore
8.50
自引率
8.60%
发文量
46
审稿时长
42 days
期刊介绍: Giant is an interdisciplinary title focusing on fundamental and applied macromolecular science spanning all chemistry, physics, biology, and materials aspects of the field in the broadest sense. Key areas covered include macromolecular chemistry, supramolecular assembly, multiscale and multifunctional materials, organic-inorganic hybrid materials, biophysics, biomimetics and surface science. Core topics range from developments in synthesis, characterisation and assembly towards creating uniformly sized precision macromolecules with tailored properties, to the design and assembly of nanostructured materials in multiple dimensions, and further to the study of smart or living designer materials with tuneable multiscale properties.
期刊最新文献
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