{"title":"大麻植物材料中大麻二酚（CBD）和 Δ9-THC 的光降解。","authors":"Arianna Bini, Sofia Salerno, Stefano Protti, Federica Pollastro, Antonella Profumo, Luca Morini, Daniele Merli","doi":"10.1007/s43630-024-00589-4","DOIUrl":null,"url":null,"abstract":"<p><p>Δ<sup>9</sup>-THC, the psychotropic cannabinoid in Cannabis sativa L., for many years has been the focus of all the pharmacological attention as the main promising principle of the plant. Recently, however, cannabidiol (CBD) has brought a sudden change in the scenario, exponentially increasing the interest in pharmacology as the main non-psychotropic cannabinoid with potential therapeutic, cosmetical and clinical applications. Although the reactivity of CBD and Δ<sup>9</sup>-THC has been considered, little attention has been paid to the possible photodegradation of these cannabinoids in the vegetal matrix and the data available in the literature are, in some cases, contradictory. The aim of the present work is to provide a characterization of the photochemical behaviour of CBD and Δ<sup>9</sup>-THC in three cannabis chemotypes, namely I (Δ<sup>9</sup>-THC 2.50%<sub>w/w</sub>), II (CBD:Δ<sup>9</sup>-THC 5.82%<sub>w/w</sub>:3.19%<sub>w/w</sub>) and III (CBD 3.02%<sub>w/w</sub>).</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photodegradation of cannabidiol (CBD) and Δ<sup>9</sup>-THC in cannabis plant material.\",\"authors\":\"Arianna Bini, Sofia Salerno, Stefano Protti, Federica Pollastro, Antonella Profumo, Luca Morini, Daniele Merli\",\"doi\":\"10.1007/s43630-024-00589-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Δ<sup>9</sup>-THC, the psychotropic cannabinoid in Cannabis sativa L., for many years has been the focus of all the pharmacological attention as the main promising principle of the plant. Recently, however, cannabidiol (CBD) has brought a sudden change in the scenario, exponentially increasing the interest in pharmacology as the main non-psychotropic cannabinoid with potential therapeutic, cosmetical and clinical applications. Although the reactivity of CBD and Δ<sup>9</sup>-THC has been considered, little attention has been paid to the possible photodegradation of these cannabinoids in the vegetal matrix and the data available in the literature are, in some cases, contradictory. The aim of the present work is to provide a characterization of the photochemical behaviour of CBD and Δ<sup>9</sup>-THC in three cannabis chemotypes, namely I (Δ<sup>9</sup>-THC 2.50%<sub>w/w</sub>), II (CBD:Δ<sup>9</sup>-THC 5.82%<sub>w/w</sub>:3.19%<sub>w/w</sub>) and III (CBD 3.02%<sub>w/w</sub>).</p>\",\"PeriodicalId\":98,\"journal\":{\"name\":\"Photochemical & Photobiological Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photochemical & Photobiological Sciences\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s43630-024-00589-4\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photochemical & Photobiological Sciences","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s43630-024-00589-4","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/13 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Photodegradation of cannabidiol (CBD) and Δ9-THC in cannabis plant material.
Δ9-THC, the psychotropic cannabinoid in Cannabis sativa L., for many years has been the focus of all the pharmacological attention as the main promising principle of the plant. Recently, however, cannabidiol (CBD) has brought a sudden change in the scenario, exponentially increasing the interest in pharmacology as the main non-psychotropic cannabinoid with potential therapeutic, cosmetical and clinical applications. Although the reactivity of CBD and Δ9-THC has been considered, little attention has been paid to the possible photodegradation of these cannabinoids in the vegetal matrix and the data available in the literature are, in some cases, contradictory. The aim of the present work is to provide a characterization of the photochemical behaviour of CBD and Δ9-THC in three cannabis chemotypes, namely I (Δ9-THC 2.50%w/w), II (CBD:Δ9-THC 5.82%w/w:3.19%w/w) and III (CBD 3.02%w/w).
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