病例报告：[18F]FAPI-42正电子发射计算机断层成像（PET/CT）显示[18F]FDG检测不到的原发性腺样囊性癌。

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI:10.62347/WSUV5599

Zehao Wang, Zheng Liu, Lulu Zhuang, Weihua Yin, Yongsheng Zhao, Mengjie Dong

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引用次数: 0

摘要

腺样囊性癌（ACC）是一种罕见的唾液腺癌症。但其生长和侵袭进展缓慢，血行转移是 ACC 最常见的远处转移。由于成纤维细胞活化蛋白（FAP）在肿瘤基质中的广泛表达和低背景摄取，FAPI被认为是除FDG之外ACC的另一种潜在示踪剂。在本病例中，我们报告了一名通过细针穿刺活检（FNAB）确诊为转移性 ACC 肝癌的患者，并接受了[18F]FDG 和[18F]FAPI-42 的 PET/CT 检查以寻找原发癌灶。最后，在左侧颌下腺发现了原发癌灶，切除后病理证实为 ACC。

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Case report: [¹⁸F]FAPI-42 PET/CT visualize primary adenoid cystic carcinoma not detected by [¹⁸F]FDG.

Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer. Still, its growth and invasion progress is slow, and its hematogenous metastasis is ACC's most common distant metastasis. Because of the broad expression and low background uptake of fibroblast activation protein (FAP) in tumor stroma, FAPI is considered another potential tracer of ACC in addition to FDG. In this case, we report a patient who was diagnosed with metastatic ACC liver cancer by fine needle aspiration biopsy (FNAB) and underwent PET/CT examination of [¹⁸F]FDG and [¹⁸F]FAPI-42 to find the primary cancer lesion. Finally, the primary cancer lesion was found in the left submandibular gland and was pathologically confirmed as ACC after resection.

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

4.00%

发文量

期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.