天然产品在炎症中的潜力:生物活性、结构-活性关系和机理目标。

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2024-05-13 DOI:10.1007/s12272-024-01496-z
Yajing Guo, Xuling Peng, Fanfei Liu, Qi Zhang, Liqin Ding, Gen Li, Feng Qiu
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引用次数: 0

摘要

在人体中,炎症的发展和抑制之间始终存在着一种平衡。一旦这种平衡被打破,强烈的炎症反应就会损害身体。有时需要使用具有明显消炎作用的药物,如非甾体类消炎药和类固醇激素,来控制体内的炎症。然而,现有的抗炎药物有许多不良反应,严重时可致命,因此有必要研究更安全、更有效的新型抗炎药物。目前,具有抗炎活性和独特结构特征的天然产物种类繁多,这些天然产物在开发新型抗炎药物方面潜力巨大。本综述总结了近二十年来具有抗炎活性的 260 种天然产物及其衍生物,按其有效成分进行了分类,并重点研究了它们在抗炎中的结构-活性关系,为后续的新药开发奠定基础。我们还通过网络药理学预测阐明了天然产物发挥抗炎作用的机制和途径,为确定抗炎天然产物的后续靶点提供了方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets

A balance between the development and suppression of inflammation can always be found in the body. When this balance is disturbed, a strong inflammatory response can damage the body. It sometimes is necessary to use drugs with a significant anti-inflammatory effect, such as nonsteroidal anti-inflammatory drugs and steroid hormones, to control inflammation in the body. However, the existing anti-inflammatory drugs have many adverse effects, which can be deadly in severe cases, making research into new safer and more effective anti-inflammatory drugs necessary. Currently, numerous types of natural products with anti-inflammatory activity and distinct structural features are available, and these natural products have great potential for the development of novel anti-inflammatory drugs. This review summarizes 260 natural products and their derivatives with anti-inflammatory activities in the last two decades, classified by their active ingredients, and focuses on their structure–activity relationships in anti-inflammation to lay the foundation for subsequent new drug development. We also elucidate the mechanisms and pathways of natural products that exert anti-inflammatory effects via network pharmacology predictions, providing direction for identifying subsequent targets of anti-inflammatory natural products.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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