睾酮与男性心肌梗死和冠状动脉疾病严重程度的关系

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE International Journal of Cardiology Cardiovascular Risk and Prevention Pub Date : 2024-05-07 DOI:10.1016/j.ijcrp.2024.200281

Lujing Tang , Mengsha Chen , Jiahao Li , Xiaodong Xu , Xiangyuan Pu

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引用次数: 0

摘要

背景冠心病（CHD）仍然是发病和死亡的主要原因，尤其是在老龄人口中。与女性相比，男性的冠心病发病率通常更高，而睾酮水平与心血管风险成反比。本研究调查了睾酮水平与经血管造影证实的冠心病、疾病严重程度以及冠心病病例中心肌梗死（MI）之间的关系。研究收集了人口统计学、临床和生化数据，包括血清总睾酮水平。结果显示，不同冠心病亚型的睾酮水平存在显著差异，尤其是在心肌梗死组和不稳定型心绞痛/稳定型心绞痛组之间（p <0.001）。睾酮水平与冠心病严重程度成反比，Gensini 评分证明了这一点（皮尔逊系数 = -0.062，P = 0.004）。交叉验证随机森林分析表明，睾酮对鉴别心脏病严重程度有显著作用（P < 0.05）。

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Association of testosterone with myocardial infarction and severity of coronary artery disease among male patients

Background

Coronary heart disease (CHD) remains a leading cause of morbidity and mortality, particularly in aging populations. Men typically exhibit higher rates of CHD compared to women, with testosterone levels inversely associated with cardiovascular risk. This study investigates the relationship between testosterone levels and angiographically confirmed CHD, disease severity, and myocardial infarction (MI) among CHD cases.

Methods

A cohort of 1724 male patients undergoing diagnostic or interventional coronary angiography was examined. Demographic, clinical, and biochemical data were collected, including serum total testosterone levels. The severity of CHD was assessed using the Gensini score, and MI cases were diagnosed according to World Health Organization criteria.

Results

Results revealed significant differences in testosterone levels among CHD subtypes, particularly between MI and unstable angina/stable angina groups (p < 0.001). Testosterone levels were inversely correlated with CHD severity, as evidenced by the Gensini score (Pearson coefficient = −0.062, P = 0.004). Cross-validation random forest analysis demonstrated the significant contribution of testosterone to CHD severity discrimination (p < 0.05).