质子激活的 G 蛋白偶联受体在炎症中的免疫调节作用。

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current Medical Science Pub Date : 2024-06-01 Epub Date: 2024-05-15 DOI:10.1007/s11596-024-2872-4

Min-Shan Li, Xiang-Hong Wang, Heng Wang

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引用次数: 0

摘要

质子激活的 G 蛋白偶联受体（GPCR）最初由路德维希于 2003 年发现，广泛分布于各种组织中。研究发现，这些受体在炎症性肠病、特应性皮炎和哮喘等多种炎症性疾病中调节免疫系统。质子激活型 GPCR 属于 G 蛋白偶联受体家族，可以检测细胞外 pH 值的变化。这种检测会触发细胞内的下游信号通路，最终影响免疫细胞的功能。在这篇综述中，我们特别侧重于研究质子激活的 GPCR 在炎症条件下的免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation.

Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

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来源期刊

Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.70

自引率

0.00%

发文量

126

期刊介绍： Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.