María Judith Rios-Lugo, Jesús Isimar Serafín-Fabián, Héctor Hernández-Mendoza, Miguel Klünder-Klünder, Miguel Cruz, Estefania Chavez-Prieto, Israel Martínez- Navarro, Jenny Vilchis-Gil, Miguel Vazquez-Moreno
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The triglyceride-glucose (TyG) index was used as a surrogate marker to evaluate IR. Serum Mg level was negatively associated with overweight (Odds ratio [OR] = 0.377, 95% confidence interval [CI] 0.231–0.614, p < 0.001) and obesity (OR = 0.345, 95% CI 0.202–0.589, p < 0.001). Serum Mg level resulted negatively associated with body mass index (BMI, β = −1.16 ± 0.26, p < 0.001), BMI z-score (β = −0.48 ± 0.10, p < 0.001) and TyG index (β = −0.04 ± 0.04, p = 0.041). Through a mediation analysis was estimated that BMI z-score accounts for 60.5% of the negative association of serum Mg level with IR (Sobel test: z = 2.761; p = 0.005). 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引用次数: 0
摘要
背景/目的:成人血清镁(Mg)水平降低与肥胖、胰岛素抵抗(IR)、2 型糖尿病和代谢综合征有关。然而,在儿童群体中,相关证据仍然有限。在这项横断面研究中,我们旨在分析墨西哥城 189 名 6 至 12 岁学龄儿童(91 名女孩和 98 名男孩)的血清镁水平与超重和肥胖频率以及心脏代谢特征之间的关系:收集人体测量数据,并通过酶比色法测量生化参数。采用电感耦合等离子体质谱法(ICP-MS)分析血清镁含量。甘油三酯-葡萄糖(TyG)指数被用作评估 IR 的替代指标:结果:血清镁水平与超重呈负相关(Odds ratio [OR] = 0.377,95% 置信区间 [CI] 0.231-0.614,P 结论:血清镁水平与超重呈负相关:我们的研究结果表明,BMI zcore 是墨西哥学龄儿童血清镁水平与 IR 负相关的部分原因。
Mediation effect of body mass index on the association between serum magnesium level and insulin resistance in children from Mexico City
Reduced serum magnesium (Mg) levels have been associated with obesity, insulin resistance (IR), type 2 diabetes, and metabolic syndrome in adults. However, in the children population, the evidence is still limited. In this cross-sectional study, we aimed to analyze the association of serum Mg levels with the frequency of overweight and obesity and cardiometabolic traits in 189 schoolchildren (91 girls and 98 boys) between 6 and 12 years old from Mexico City. Anthropometrical data were collected and biochemical parameters were measured by enzymatic colorimetric assay. Serum Mg level was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). The triglyceride-glucose (TyG) index was used as a surrogate marker to evaluate IR. Serum Mg level was negatively associated with overweight (Odds ratio [OR] = 0.377, 95% confidence interval [CI] 0.231–0.614, p < 0.001) and obesity (OR = 0.345, 95% CI 0.202–0.589, p < 0.001). Serum Mg level resulted negatively associated with body mass index (BMI, β = −1.16 ± 0.26, p < 0.001), BMI z-score (β = −0.48 ± 0.10, p < 0.001) and TyG index (β = −0.04 ± 0.04, p = 0.041). Through a mediation analysis was estimated that BMI z-score accounts for 60.5% of the negative association of serum Mg level with IR (Sobel test: z = 2.761; p = 0.005). Our results evidence that BMI z-score mediate part of the negative association of serum Mg level and IR in Mexican schoolchildren.
期刊介绍:
The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion.
Topics of interest include but are not limited to:
Nutrition and Health (including climate and ecological aspects)
Metabolism & Metabolomics
Genomics and personalized strategies in nutrition
Nutrition during the early life cycle
Health issues and nutrition in the elderly
Phenotyping in clinical nutrition
Nutrition in acute and chronic diseases
The double burden of ''malnutrition'': Under-nutrition and Obesity
Prevention of Non Communicable Diseases (NCD)