胆碱酯酶是胃癌胃切除术后骨骼肌损失的预测指标。

IF 1.9 4区 医学 Q3 ONCOLOGY Japanese journal of clinical oncology Pub Date : 2024-09-04 DOI:10.1093/jjco/hyae065
Yasuhiro Takano, Wataru Kai, Hironori Kanno, Nobuyoshi Hanyu
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引用次数: 0

摘要

背景:胆碱酯酶是一种经典的营养和炎症标志物。本研究旨在评估胆碱酯酶作为胃癌胃切除术后骨骼肌损失的预测指标的价值:研究对象包括 68 名接受胃癌胃切除术的患者。使用骨骼质量指数评估骨骼肌质量,所有患者的骨骼质量指数变化率(术后1年/术前)小于或等于中位数即为主要骨骼肌损失。我们探讨了术后主要骨骼肌损失与无病生存率和总生存率之间的关系。然后,我们研究了胃切除术后骨骼肌指数变化率与血清胆碱酯酶水平之间的关系:结果:骨骼肌指数变化率的中位值为 0.93。术后主要骨骼肌损失与胃切除术后无病生存率显著相关(P = 0.003)。虽然大块骨骼肌缺失会降低总生存率,但并不显著(P = 0.058)。根据斯皮尔曼秩相关系数(r = 0.438,P ≤ 0.001),骨骼质量指数和胆碱酯酶的变化率与其他营养指标相比具有更强的正相关性:结论:评估血清胆碱酯酶水平可能对预测胃切除术后骨骼肌损失有价值,这表明胆碱酯酶在胃癌患者术后营养管理中的重要性。
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Cholinesterase as a predictor of skeletal muscle loss after gastrectomy for gastric cancer.

Background: Cholinesterase is a classical nutritional and inflammatory marker. The aim of the present study was to evaluate the value of cholinesterase as a predictive marker for postoperative skeletal muscle loss after gastrectomy for gastric cancer.

Methods: The study comprised 68 patients who had undergone gastrectomy for gastric cancer. Skeletal muscle mass was evaluated using skeletal mass index, and major skeletal muscle loss was defined as less than or equal to the median change rate (1-year postoperative/preoperative) of skeletal mass index in all patients. We explored the relationship between postoperative major skeletal muscle loss and disease-free survival and overall survival. Then we investigated the relationship between change rate of skeletal muscle index and serum cholinesterase levels after gastrectomy.

Results: The median value of change rate of skeletal mass index was 0.93. Postoperative major skeletal muscle loss was significantly associated with disease-free survival after gastrectomy (P = 0.003). Although major skeletal muscle loss had worse overall survival, it was not significant (P = 0.058). The change rate of skeletal mass index and cholinesterase had a stronger positive correlation compared with other nutritional indices according to Spearman's rank correlation coefficient (r = 0.438, P ≤ 0.001).

Conclusion: Evaluation of serum cholinesterase levels may be valuable for predicting postoperative skeletal muscle loss after gastrectomy, suggesting the importance of cholinesterase in postoperative nutritional management of patients with gastric cancer.

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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
177
审稿时长
3-8 weeks
期刊介绍: Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews
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