经颅直流电刺激对轻度认知障碍的疗效:荟萃分析

IF 0.8 Q4 CLINICAL NEUROLOGY Journal of Neurosciences in Rural Practice Pub Date : 2024-04-01 Epub Date: 2024-04-16 DOI:10.25259/JNRP_629_2023
G Sandhya, Palash Kumar Malo, Thomas Gregor Issac
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引用次数: 0

摘要

目的:轻度认知障碍(MCI)是一种过渡状态,患者的认知能力介于正常衰老和痴呆之间。虽然并非所有 MCI 患者都会发展成痴呆症,但 MCI 患者发展成痴呆症的风险较高。在这一阶段进行干预可以预防或延缓痴呆症的发生。近年来,有关非侵入性脑刺激技术(即经颅直流电刺激(tDCS))的研究在增强 MCI 患者认知能力方面取得了进展。由于报告结果各异的研究很少,因此分析经颅直流电刺激在 MCI 中的效果变得非常重要。本研究的目的是系统回顾有关使用 tDCS 治疗 MCI 的现有证据,并使用荟萃分析法评估其疗效:研究纳入了八项单盲或双盲随机对照试验。研究考虑了蒙特利尔认知评估(MoCA)和迷你精神状态检查(MMSE)对整体认知的影响,以及数字跨度测试(前向和后向)、线索制作测试(TMT)A 和 B,以及逻辑记忆测试(LMT)对特定认知领域的影响。研究采用随机效应模型,报告了标准化平均差(SMD)及其 95% 置信区间:结果:与假性 tDCS 相比,活性 tDCS(MoCA [SMD 0.37, 95% CI -0.22-0.95]、MMSE [SMD 0.26, 95% CI 0.25-0.77]、TMT-A [SMD -0.01, 95% CI -0.42-0.40]和 LMT [SMD 0.80, 95% CI -0.24-1.83])的效果在统计学上并不显著:目前的荟萃分析发现,与假tDCS相比,主动tDCS治疗对MCI患者认知能力的改善并不显著。
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Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis.

Objectives: Mild cognitive impairment (MCI) is a transition state in which individuals have cognitive abilities that are in between those of normal aging and dementia. Although not everyone with MCI develops dementia, the risk of progression to dementia is higher in people with MCI. Interventions at this stage can prevent or delay the onset of dementia. In recent years, studies on non-invasive brain stimulation techniques, namely transcranial direct current stimulation (tDCS), have gained momentum for cognitive enhancement in MCI. Since there are very few studies that also report varied results, it becomes important to analyze the effect of tDCS in MCI. The aim of this study was to systematically review the available evidence about using tDCS for MCI and to assess its efficacy using meta-analysis.

Materials and methods: Eight single- or double-blinded randomized controlled trials were included in the study. Montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE) for global cognition; and digit span test forward and backward, trail-making test (TMT) A and B; and logical memory test (LMT) assessing specific cognitive domains were considered. A random-effects model was used wherein the standardized mean difference (SMD) and its 95% confidence intervals were reported.

Results: The effect of the active tDCS (MoCA [SMD 0.37, 95% CI -0.22-0.95], MMSE [SMD 0.26, 95% CI 0.25-0.77], TMT-A [SMD -0.01, 95% CI -0.42-0.40], and LMT [SMD 0.80, 95% CI -0.24-1.83]) when compared with the sham tDCS was statistically insignificant.

Conclusion: The current meta-analysis identified insignificant improvement in cognitive performance with active tDCS treatment as compared to sham tDCS among people with MCI.

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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
129
审稿时长
22 weeks
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