R. R. Davletshin, R. R. Galeev, I. R. Aryslanov, E. V. Galeeva, A. N. Sedov
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A Study of the Thermal Degradation of Amoxicillin Trihydrate Using Raman Spectroscopy and High-Performance Liquid Chromatography
High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the thermal degradation of amoxicillin trihydrate. Heating this compound at 60°C for 6 h led to an increase in the impurity contents, each not exceeding 1%. HPLC and Raman spectroscopy can be used to evaluate the quality of an amoxicillin sample obtained after thermal degradation at 80°C.
期刊介绍:
Journal of Applied Spectroscopy reports on many key applications of spectroscopy in chemistry, physics, metallurgy, and biology. An increasing number of papers focus on the theory of lasers, as well as the tremendous potential for the practical applications of lasers in numerous fields and industries.