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引用次数: 0
摘要
本文报告了一种选择性和高效的二氧化碳介导的烯酰胺 Z 到 E 异构化反应。值得注意的是,二氧化碳是形成关键反应中间体的促进剂。该方案提供了一种在温和条件下选择性异构化烯酰胺的新方法,并具有中等到极好的产率。该方法具有广泛的底物范围,包括生物相关分子的后期修饰。通过循环伏安法 (CV) 和密度泛函理论 (DFT) 计算得出的机理结论证明,中间体通过非常规的 C-中心模式促进了反应的进行。
Herein, a selective and efficient CO2-mediated Z to E isomerization of enamides is reported. Notably, CO2 acts as a promoter to form the key reaction intermediate. This protocol provides a novel method for the selective isomerization of enamides under mild conditions with moderate to excellent yields. The method exhibits a broad substrate scope, including late-stage modification of biorelevant molecules. Mechanistic insights by means of cyclic voltammetry (CV) and density functional theory (DFT) calculation offer evidence that the reaction is promoted by the intermediate via unconventional C-centered mode.
期刊介绍:
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.