Withaferin-A 和蜂胶联合药物疗法对乳腺癌的治疗潜力:验证苯并[a]芘诱发乳腺癌转移的抗增殖疗效和改善潜力的体内解读

IF 2.8 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Journal of Chemistry Pub Date : 2024-05-14 DOI:10.1155/2024/8491275
Meghalatha T. S., Arumugam Suresh, Muninathan Natrajan, Kuppusamy Baskaran, Shobana Sampath, Elumalai Perumal, E. Madhav, Mohammad Z. Ahmed, Ali S. Alqahtani, Shadab Kazmi, Asaithambi Perumal
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引用次数: 0

摘要

癌症是一个严重的健康问题,全球癌症发病率呈上升趋势。女性乳腺癌是全球最常见的癌症类型,治疗方法包括乳房切除术、化疗和放疗等不同策略。人们已经对睡莲的一种生物活性化合物--withaferin-A(WA)的抗癌特性进行了研究。另一种从蜜蜂中提取的天然物质--蜂胶,也被研究用于治疗人类疾病。本研究的目的是探讨枯草素-A 和蜂胶联合药物疗法对乳腺癌细胞的改善功效和抗增殖潜力。本研究通过评估苯并[a]芘诱导的雌性 Wistar 大鼠乳腺癌细胞中糖蛋白、核酸和标志酶的水平,考察了黄铁素-A 和蜂胶联合用药的药效学效应。肝脏中 DNA、RNA 和蛋白质水平的生化分析表明,蜂胶疗法具有典型的效果。白花蛇舌草素-A和蜂胶药物联合治疗可显著减少核酸合成,表明联合化疗可提高乳腺癌的杀瘤效率。药物联合疗法显示出控制与肿瘤生长相关的糖蛋白(己糖、己胺和硅铝酸)的能力,检测到它们的水平大幅下降。乳腺的组织病理学分析表明,增生和细胞增殖有所减少,这表明该疗法有能力逆转与乳腺癌相关的结构和形态异常。这项研究发现,在给携带乳腺癌基因的老鼠服用天然药物复合物组合后,显示出再生和调节作用。
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Therapeutic Potential of Withaferin-A and Propolis Combinational Drug Therapy for Breast Cancer: An In Vivo Interpretation for Validating the Antiproliferative Efficacy and Ameliorative Potential in Benzo[a]pyrene-Induced Breast Metastasis
Cancer is a serious health problem, with a rising trend in its occurrence documented globally. Female breast cancer is the most common type of cancer worldwide with treatment consisting of different strategies like mastectomy, chemotherapy, and radiotherapy. Anticancer property has been studied in withaferin-A (WA), a bioactive compound of Withania somnifera. Another natural substance derived from bees, propolis, has been investigated for many beneficial effects on human diseases. The current study aims to investigate the ameliorative efficacy and antiproliferative potential of combinational drug therapy of withaferin-A and propolis on breast cancer cells. By evaluating the levels of glycoproteins, nucleic acids, and the marker enzymes in benzo[a]pyrene-induced breast cancer-bearing female Wistar rats, the pharmacodynamic effects of withaferin-A and propolis drug combination were examined. Biochemical analysis of DNA, RNA, and protein levels in the liver demonstrated typical results after propolis therapy. Withaferin-A and propolis drug combination treatment significantly decreased nucleic acid synthesis, indicating that combination chemotherapy has increased breast tumoricidal efficiency. The pharmacological combination therapy exhibited the capacity to control glycoproteins associated with tumor growth (hexose, hexosamine, and sialic acid), with a considerable decrease in their levels detected. Histopathological analysis of the mammary glands demonstrated a decrease in hyperplasia and cell proliferation, indicating that the treatment has the ability to reverse architectural and morphological abnormalities associated with breast cancer. This study found that natural drug compounds in combination have shown regenerative and regulating effects when given to rats carrying the breast cancer gene.
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来源期刊
Journal of Chemistry
Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
5.90
自引率
3.30%
发文量
345
审稿时长
16 weeks
期刊介绍: Journal of Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry.
期刊最新文献
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