Ines Horvat-Menih, Alixander S Khan, Mary A McLean, Joao Duarte, Eva Serrao, Stephan Ursprung, Joshua D Kaggie, Andrew B Gill, Andrew N Priest, Mireia Crispin-Ortuzar, Anne Y Warren, Sarah J Welsh, Thomas J Mitchell, Grant D Stewart, Ferdia A Gallagher
{"title":"超极化 13C-MRI 的 K-means 聚类确定肾细胞癌的瘤内灌注/代谢错配是最高分级的最佳预测指标","authors":"Ines Horvat-Menih, Alixander S Khan, Mary A McLean, Joao Duarte, Eva Serrao, Stephan Ursprung, Joshua D Kaggie, Andrew B Gill, Andrew N Priest, Mireia Crispin-Ortuzar, Anne Y Warren, Sarah J Welsh, Thomas J Mitchell, Grant D Stewart, Ferdia A Gallagher","doi":"10.1101/2024.05.06.24306829","DOIUrl":null,"url":null,"abstract":"<strong>Purpose</strong> Conventional renal mass biopsy approaches are inaccurate, potentially leading to undergrading. This study explored using hyperpolarised [1-<sup>13</sup>C]pyruvate MRI (HP <sup>13</sup>C-MRI) to identify the most aggressive areas within the tumour of patients with clear cell renal cell carcinoma (ccRCC).","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"160 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"K-means clustering of hyperpolarised 13C-MRI identifies intratumoural perfusion/metabolism mismatch in renal cell carcinoma as best predictor of highest grade\",\"authors\":\"Ines Horvat-Menih, Alixander S Khan, Mary A McLean, Joao Duarte, Eva Serrao, Stephan Ursprung, Joshua D Kaggie, Andrew B Gill, Andrew N Priest, Mireia Crispin-Ortuzar, Anne Y Warren, Sarah J Welsh, Thomas J Mitchell, Grant D Stewart, Ferdia A Gallagher\",\"doi\":\"10.1101/2024.05.06.24306829\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Purpose</strong> Conventional renal mass biopsy approaches are inaccurate, potentially leading to undergrading. This study explored using hyperpolarised [1-<sup>13</sup>C]pyruvate MRI (HP <sup>13</sup>C-MRI) to identify the most aggressive areas within the tumour of patients with clear cell renal cell carcinoma (ccRCC).\",\"PeriodicalId\":501358,\"journal\":{\"name\":\"medRxiv - Radiology and Imaging\",\"volume\":\"160 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Radiology and Imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.05.06.24306829\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Radiology and Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.05.06.24306829","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
K-means clustering of hyperpolarised 13C-MRI identifies intratumoural perfusion/metabolism mismatch in renal cell carcinoma as best predictor of highest grade
Purpose Conventional renal mass biopsy approaches are inaccurate, potentially leading to undergrading. This study explored using hyperpolarised [1-13C]pyruvate MRI (HP 13C-MRI) to identify the most aggressive areas within the tumour of patients with clear cell renal cell carcinoma (ccRCC).
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