二羟基香豆素的新钴配合物：合成及其氧化还原激活解离动力学

IF 1.1 3区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR Russian Journal of Coordination Chemistry Pub Date : 2024-05-08 DOI:10.1134/S1070328423600663

K. A. Spiridonov, I. A. Nikovskii, E. P. Antoshkina, E. A. Khakina, Yu. V. Nelyubina

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引用次数: 0

摘要

摘要合成了一种新的具有氧化还原活性的钴(III)配合物，该配合物含有 2-oxo-2Н-chromene-6,7-diolate 二离子和 4,4'-dimethoxy-2,2'-bipyridine 配体。在惰性气氛中，利用核磁共振光谱对合成复合物与抗坏血酸的还原过程进行了原位研究。研究表明，还原过程会导致作为模型药物的 6,7-二氢香豆素的释放。这一过程对于初始复合物而言是一阶的。

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New Cobalt Complex with Dihydroxycoumarin: Synthesis and Kinetics of Its Redox-Activated Dissociation

A new redox-active cobalt(III) complex containing the 2-oxo-2Н-chromene-6,7-diolate dianion and 4,4'-dimethoxy-2,2'-bipyridine as ligands is synthesized. The reduction of the synthesized complex with ascorbic acid in an inert atmosphere is studied in situ by NMR spectroscopy. The reduction is shown to result in the release of 6,7-dihydrocycoumarin acting as a model drug. This process has the first order with respect to the initial complex.

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来源期刊

Russian Journal of Coordination Chemistry 化学-无机化学与核化学

CiteScore

2.40

自引率

15.80%

发文量

审稿时长

7.2 months

期刊介绍： Russian Journal of Coordination Chemistry is a journal that publishes reviews, original papers, and short communications on all aspects of theoretical and experimental coordination chemistry. Modern coordination chemistry is an interdisciplinary science that makes a bridge between inorganic, organic, physical, analytical, and biological chemistry.