脑外伤史与阿尔茨海默病患者皮质厚度纵向变化之间的关系

IF 4.3 Q2 BUSINESS The Journal of Prevention of Alzheimer's Disease Pub Date : 2024-05-09 DOI:10.14283/jpad.2024.86

G. M. D’Souza, N. W. Churchill, D. X. Guan, M. A. Khoury, S. J. Graham, S. Kumar, C. E. Fischer, Tom A. Schweizer

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引用次数: 0

摘要

背景很少有人直接研究过创伤性脑损伤（TBI）如何影响阿尔茨海默病（AD）患者的神经变性率。根据基线和随访（平均间隔 33.4 个月）时的 T1 加权磁共振成像扫描结果量化皮质厚度。结果在整个额叶和颞叶皮层中发现了显著的群体效应。结论这些结果表明，有创伤性脑损伤史会加剧 AD 患者皮质厚度的纵向下降，从而为了解这些神经疾病之间的共同病理机制提供了新的视角。

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The Relationship between History of Traumatic Brain Injury and Longitudinal Changes in Cortical Thickness among Patients with Alzheimer’s Disease

Background

There has been little direct examination of how traumatic brain injury (TBI) affects the rate of neurodegeneration for individuals with Alzheimer’s disease (AD).

Methods

The study examined 89 cognitively normal adults (65 with and 24 without prior TBI) and 65 with AD (16 with and 49 without prior TBI). Cortical thickness was quantified from T1-weighted MRI scans at baseline and follow-up (mean interval 33.4 months). Partial least squares analysis was used to evaluate the effects of AD and TBI history on the longitudinal change in cortical thickness.

Results

Significant group effects were identified throughout the frontal and temporal cortices. Comparison of the AD groups to their control cohorts showed greater relative atrophy for the AD cohort with prior TBI.

Conclusion

These results indicate that a history of TBI exacerbates longitudinal declines in cortical thickness among AD patients, providing new insights into the shared pathomechanisms between these neurological conditions.

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来源期刊

The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health

CiteScore

9.20

自引率

0.00%

发文量

期刊介绍： The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.