一种新型水溶性喹喔啉并[2,3-a]吩嗪基有机近红外光热剂在癌症光疗中的应用

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Chemical Sciences Pub Date : 2024-05-09 DOI:10.1007/s12039-024-02262-w

Siqi Liu, Xu Zhao, Hongying Ding, Liuyi Yang, Meng Zhao, Gaolei Xi, Tao Jia

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摘要

有机近红外（NIR）光热剂在癌症治疗中具有巨大潜力。本文报道了一种新型近红外光响应光热剂 DDHT/F127 胶束，它具有优异的光热性能和光稳定性，在癌症光疗中效果显著。图解摘要一种新型的供体-受体（D-A）型有机光热材料5,18-二丁基-5,18-二氢-二喹喔啉[2,3-a:2',3'-c]-吩嗪（DDHT）与Pluronic® 127（F127）材料包裹成近红外光响应光热剂DDHT/F127胶束，该光热剂具有优异的光热性能，在655 nm的近红外波长下光热转换效率为51.在 655 纳米近红外激光照射下，其光热转换效率为 51.

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A novel water-soluble quinoxalino[2,3-a] phenazine-based organic NIR photothermal agent for cancer phototherapy application

Organic near-infrared (NIR) photothermal agents have tremendous potential in cancer therapy. Herein we report anovel NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties and photostability, along with outstanding outcomes in cancer phototherapy.

Graphical abstract

A novel donor-acceptor (D-A)-type organic photothermal material 5,18-dibutyl-5,18- dihydro-diquinoxaline[2,3-a:2',3'-c]-phenazine (DDHT) was encapsulated with Pluronic^® 127 (F127) material to form NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties with photothermal conversion efficiency of 51.55% under 655 nm NIR laser irradiation, along with outstanding outcomes in cancer therapy.

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.