用布地奈德口腔分散片成功治疗食道扁平苔藓:病例报告。

IF 0.5 Q4 GASTROENTEROLOGY & HEPATOLOGY Case Reports in Gastroenterology Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI:10.1159/000538894
Harald Bagger-Jörgensen, Mohammed Abdulrasak, Kevin Sandeman, Mohammed Binsalman, Klas Sjöberg
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引用次数: 0

摘要

简介扁平苔藓是一种比较常见的指甲、皮肤和粘膜表面炎症。扁平苔藓累及食道被认为非常罕见,主要见于病例报告,但与食道狭窄和鳞状细胞癌的高风险相关。目前尚无循证治疗建议,大多数描述的治疗方案都涉及全身免疫抑制:在本病例报告中,我们介绍了一种使用布地奈德口崩片剂治疗食管扁平苔藓患者的新方法,布地奈德口崩片剂通常用于治疗嗜酸性粒细胞性食管炎。该患者的吞咽困难得到了完全缓解,治疗开始 2 个月后进行的食道胃十二指肠镜随访检查显示,其宏观和微观均无炎症活动。据我们所知,本病例报告是首次报道食道扁平苔藓的这种治疗方案:我们认为试用布地奈德口服分散片是一种合理的初始治疗方法,因为它是一种针对食道的局部治疗方法,与全身性免疫抑制相比副作用更小。此外,鉴于食道扁平苔藓的严重性和恶变可能性,我们建议医生在对已知扁平苔藓患者进行吞咽困难检查时,应谨慎要求患者接受食道胃十二指肠镜检查并进行活检。
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Oesophageal Lichen Planus Successfully Treated with Budesonide Orodispersible Tablets: A Case Report.

Introduction: Lichen planus is a relatively common inflammatory condition of the nails, skin, and mucosal surfaces. Oesophageal involvement of lichen planus is thought to be very rare, mainly described in case reports, but is associated with a high risk of oesophageal stenosis as well as squamous cell carcinoma. No evidence-based treatment recommendations exist, with the majority of described treatment regimens involving systemic immunosuppression.

Case report: In this case report, we describe a novel approach in treating oesophageal lichen planus in a patient with budesonide orodispersible tablets, a treatment normally reserved for eosinophilic oesophagitis. The patient achieved complete relief of dysphagia, with a follow-up oesophagogastroduodenoscopy 2 months after treatment commencement being macroscopically and microscopically free of inflammatory activity. This case report is to our knowledge the first to report this treatment regimen in oesophageal lichen planus.

Conclusion: We consider a trial of budesonide orodispersible tablets a reasonable initial management as it's a local therapy specific to the oesophagus with a more benign side effect profile than systemic immunosuppression, but further studies need to be undertaken to corroborate our findings. Also, based on the severity and malignant potential of oesophageal lichen planus, we suggest that physicians be liberal in ordering oesophagogastroduodenoscopy with biopsy taking as part of the workup of dysphagia in a patient with known lichen planus.

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来源期刊
Case Reports in Gastroenterology
Case Reports in Gastroenterology Medicine-Gastroenterology
CiteScore
1.10
自引率
0.00%
发文量
99
审稿时长
7 weeks
期刊介绍:
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