硫酸肝素蛋白多糖:通过隧道纳米管介导细胞和分子阿尔茨海默病致病因子?

IF 2.6 3区 医学 Q3 NEUROSCIENCES Molecular and Cellular Neuroscience Pub Date : 2024-05-13 DOI:10.1016/j.mcn.2024.103936
Duy L.B. Nguyen , Rachel K. Okolicsanyi , Larisa M. Haupt
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引用次数: 0

摘要

神经系统疾病影响着全球约十亿人(约占 15%),对残疾和死亡率产生了重大影响,目前澳大利亚每年有 680 万人死于神经系统疾病。肝素硫酸酯蛋白多糖(HSPGs)是一种复杂的细胞外分子,与促进Tau纤维形成有关,导致Tau缠结,而Tau缠结是阿尔茨海默病(AD)的特征之一。HSPG-Tau 蛋白相互作用主要通过与 glypican 1 和 syndecan 3 核心蛋白的相互作用,通过聚集、毒性和清除作用,对阿尔茨海默病的各个阶段起作用。隧道纳米管(TNTs)途径正在成为细胞间分子(包括Tau和淀粉样β蛋白)远距离运输的促进因素。虽然目前与 TNT 相关的证据主要来自癌症模型,但它们在 Tau 传播中的作用及其对受体细胞的影响仍不清楚。本综述探讨了TNTs、HSPGs和AD相关因子的相互作用,并提出HSPGs会影响神经退行性疾病(如AD)中TNT的形成。
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Heparan sulfate proteoglycans: Mediators of cellular and molecular Alzheimer's disease pathogenic factors via tunnelling nanotubes?

Neurological disorders impact around one billion individuals globally (15 % approx.), with significant implications for disability and mortality with their impact in Australia currently amounts to 6.8 million deaths annually. Heparan sulfate proteoglycans (HSPGs) are complex extracellular molecules implicated in promoting Tau fibril formation resulting in Tau tangles, a hallmark of Alzheimer's disease (AD). HSPG-Tau protein interactions contribute to various AD stages via aggregation, toxicity, and clearance, largely via interactions with the glypican 1 and syndecan 3 core proteins. The tunnelling nanotubes (TNTs) pathway is emerging as a facilitator of intercellular molecule transport, including Tau and Amyloid β proteins, across extensive distances. While current TNT-associated evidence primarily stems from cancer models, their role in Tau propagation and its effects on recipient cells remain unclear. This review explores the interplay of TNTs, HSPGs, and AD-related factors and proposes that HSPGs influence TNT formation in neurodegenerative conditions such as AD.

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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
65
审稿时长
37 days
期刊介绍: Molecular and Cellular Neuroscience publishes original research of high significance covering all aspects of neurosciences indicated by the broadest interpretation of the journal''s title. In particular, the journal focuses on synaptic maintenance, de- and re-organization, neuron-glia communication, and de-/regenerative neurobiology. In addition, studies using animal models of disease with translational prospects and experimental approaches with backward validation of disease signatures from human patients are welcome.
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