{"title":"静脉注射免疫球蛋白成功治疗进行性多灶性白质脑病","authors":"Swansu Batra, Ruchika Tandon, Saurabh Nigam","doi":"10.1016/j.nerep.2024.100214","DOIUrl":null,"url":null,"abstract":"<div><p>A 52-year-old lady developed apathy, reduced verbal output, decreased visuospatial orientation, cognitive decline, visual impairment and left hemiparesis for 4 months. On MRI head, she displayed T2/FLAIR asymmetric white matter hyperintensities in parietal and occipital lobes and cerebellar peduncle and her CSF PCR was positive for John Cunningham (JC) virus and HIV ELISA and other bacterial, mycobacterial and viral markers were negative, confirming Progressive multifocal leukoencephalopathy (PML). Thereafter, we administered monthly intravenous immunoglobulin (IVIg) and patient's condition and neuroimaging has been improving for past 8 months. Hence, IVIg improving the condition of a potentially fatal disease patient, offers some hope.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100214"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X24000159/pdfft?md5=bf17e38c5cb88fa4347a2b32e7aff696&pid=1-s2.0-S2667257X24000159-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Progressive multifocal leukoencephalopathy successfully treated with intravenous immunoglobulin\",\"authors\":\"Swansu Batra, Ruchika Tandon, Saurabh Nigam\",\"doi\":\"10.1016/j.nerep.2024.100214\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A 52-year-old lady developed apathy, reduced verbal output, decreased visuospatial orientation, cognitive decline, visual impairment and left hemiparesis for 4 months. On MRI head, she displayed T2/FLAIR asymmetric white matter hyperintensities in parietal and occipital lobes and cerebellar peduncle and her CSF PCR was positive for John Cunningham (JC) virus and HIV ELISA and other bacterial, mycobacterial and viral markers were negative, confirming Progressive multifocal leukoencephalopathy (PML). Thereafter, we administered monthly intravenous immunoglobulin (IVIg) and patient's condition and neuroimaging has been improving for past 8 months. Hence, IVIg improving the condition of a potentially fatal disease patient, offers some hope.</p></div>\",\"PeriodicalId\":100950,\"journal\":{\"name\":\"Neuroimmunology Reports\",\"volume\":\"5 \",\"pages\":\"Article 100214\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667257X24000159/pdfft?md5=bf17e38c5cb88fa4347a2b32e7aff696&pid=1-s2.0-S2667257X24000159-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroimmunology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667257X24000159\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimmunology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667257X24000159","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Progressive multifocal leukoencephalopathy successfully treated with intravenous immunoglobulin
A 52-year-old lady developed apathy, reduced verbal output, decreased visuospatial orientation, cognitive decline, visual impairment and left hemiparesis for 4 months. On MRI head, she displayed T2/FLAIR asymmetric white matter hyperintensities in parietal and occipital lobes and cerebellar peduncle and her CSF PCR was positive for John Cunningham (JC) virus and HIV ELISA and other bacterial, mycobacterial and viral markers were negative, confirming Progressive multifocal leukoencephalopathy (PML). Thereafter, we administered monthly intravenous immunoglobulin (IVIg) and patient's condition and neuroimaging has been improving for past 8 months. Hence, IVIg improving the condition of a potentially fatal disease patient, offers some hope.
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