与双相情感障碍认知和情绪状态相关的生物标志物系统综述。

IF 2.8 2区 医学 Q2 PSYCHIATRY International Journal of Bipolar Disorders Pub Date : 2024-05-17 DOI:10.1186/s40345-024-00340-z
Anaid Pérez-Ramos, Cristina Romero-López-Alberca, Maria Hidalgo-Figueroa, Esther Berrocoso, Jose I Pérez-Revuelta
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引用次数: 0

摘要

背景:双相情感障碍(BD)是一种严重的精神疾病,其特征是情绪在(低)躁狂或抑郁以及混合状态之间交替变化,通常伴有功能障碍和认知功能障碍。但人们对导致认知障碍发展和持续的生物标志物知之甚少。本研究旨在回顾不同情绪状态下神经认知与生物标志物之间的关联:搜索数据库为 Web of Science、Scopus 和 PubMed。按照 PRISMA 指南进行了系统性综述。采用纽卡斯尔-渥太华量表评估偏倚风险。所选研究主要关注神经影像学、生理学、遗传学或外周生物标志物与 BD 至少两个阶段(抑郁、(低)躁狂、嗜睡或混合)的认知之间的相关性。PROSPERO注册号:CRD42023410782:共筛选了 1824 篇参考文献,确定了 1023 篇已发表的文章,其中 336 篇被认为符合条件。只有 16 篇文章提供了有关 BD 不同情感状态下生物标志物与认知之间关系的信息。纳入的研究发现:(i) 总胆固醇和 C 反应蛋白的水平因情绪状态而异;(ii) 认知与外周生物标志物之间没有关联;(iii) 神经影像生物标志物强调额叶区域的低活化是急性 BD 状态的特征;(iv) 腹内侧前额叶皮层(vmPFC)有失活的报道,有可能成为 BD 的特征标志物:结论:近期只有少数文章研究了BD情绪阶段的生物标志物与认知之间的关联。我们的研究结果表明,在所有情绪状态下,似乎都有一些中心区域与 BD 有关。然而,在 BD 的不同情绪状态下,认知功能障碍的潜在机制可能有所不同。这篇综述强调了数据标准化和认知评估的重要性,以及对生物标志物的需求,以帮助预防疾病的急性症状阶段以及相关的功能和认知障碍。
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A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder.

Background: Bipolar disorder (BD) is a severe psychiatric disorder characterized by changes in mood that alternate between (hypo) mania or depression and mixed states, often associated with functional impairment and cognitive dysfunction. But little is known about biomarkers that contribute to the development and sustainment of cognitive deficits. The aim of this study was to review the association between neurocognition and biomarkers across different mood states.

Method: Search databases were Web of Science, Scopus and PubMed. A systematic review was carried out following the PRISMA guidelines. Risk of bias was assessed with the Newcastle-Ottawa Scale. Studies were selected that focused on the correlation between neuroimaging, physiological, genetic or peripheral biomarkers and cognition in at least two phases of BD: depression, (hypo)mania, euthymia or mixed. PROSPERO Registration No.: CRD42023410782.

Results: A total of 1824 references were screened, identifying 1023 published articles, of which 336 were considered eligible. Only 16 provided information on the association between biomarkers and cognition in the different affective states of BD. The included studies found: (i) Differences in levels of total cholesterol and C reactive protein depending on mood state; (ii) There is no association found between cognition and peripheral biomarkers; (iii) Neuroimaging biomarkers highlighted hypoactivation of frontal areas as distinctive of acute state of BD; (iv) A deactivation failure has been reported in the ventromedial prefrontal cortex (vmPFC), potentially serving as a trait marker of BD.

Conclusion: Only a few recent articles have investigated biomarker-cognition associations in BD mood phases. Our findings underline that there appear to be central regions involved in BD that are observed in all mood states. However, there appear to be underlying mechanisms of cognitive dysfunction that may vary across different mood states in BD. This review highlights the importance of standardizing the data and the assessment of cognition, as well as the need for biomarkers to help prevent acute symptomatic phases of the disease, and the associated functional and cognitive impairment.

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来源期刊
International Journal of Bipolar Disorders
International Journal of Bipolar Disorders Medicine-Psychiatry and Mental Health
CiteScore
6.70
自引率
5.00%
发文量
26
审稿时长
13 weeks
期刊介绍: The International Journal of Bipolar Disorders is a peer-reviewed, open access online journal published under the SpringerOpen brand. It publishes contributions from the broad range of clinical, psychological and biological research in bipolar disorders. It is the official journal of the ECNP-ENBREC (European Network of Bipolar Research Expert Centres ) Bipolar Disorders Network, the International Group for the study of Lithium Treated Patients (IGSLi) and the Deutsche Gesellschaft für Bipolare Störungen (DGBS) and invites clinicians and researchers from around the globe to submit original research papers, short research communications, reviews, guidelines, case reports and letters to the editor that help to enhance understanding of bipolar disorders.
期刊最新文献
Correction: Perceived cognitive loss, symptomology, and psychological well-being with bipolar disorder. Prodromal symptoms of a first manic episode: a qualitative study to the perspectives of patients with bipolar disorder and their caregivers'. Aripiprazole once-monthly for the treatment of adult patients with earlier-stage bipolar I disorder: a post hoc analysis of data from a double-blind, placebo-controlled, 52-week randomized withdrawal trial. Correction: Effectiveness of ultra-long-term lithium treatment: relevant factors and case series. Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review.
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