神经雌激素在雌激素诱导雄猴促性腺激素激增中的作用。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-17 DOI:10.1111/jne.13413
Mohammad S. Biswas, Erica M. Gelman, Daniel J. Alexopoulos, Kim L. Keen, Ryan J. Adam, Ei Terasawa
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引用次数: 0

摘要

众所周知,大脑中合成的神经雌激素在性行为中扮演着重要角色。然而,神经雌激素是否参与调节促性腺激素释放激素(GnRH)的释放这一问题才刚刚出现。由于本实验室之前的研究表明,神经雌二醇对雌性恒河猴GnRH的脉冲式释放和激增式释放也很重要,因此在本研究中,我们考察了神经雌二醇是否在睾丸切除(ORX)雄性恒河猴雌激素诱导的LH激增中发挥作用。与啮齿类动物不同,已知大剂量雌激素治疗可导致睾丸切除雄性恒河猴的 LH 激增。结果表明,与卵巢切除的雌性恒河猴不同,神经雌激素在外源性雌激素诱导的恒河猴LH激增实验中不起作用。
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The role of neuroestrogens in the estrogen-induced gonadotropin surge in male monkeys

Neuroestrogens locally synthesized in the brain are known to play a role in sexual behaviors. However, the question of whether neuroestrogens are involved in the regulation of the gonadotropin-releasing hormone (GnRH) release is just emerging. Because previous studies in this lab indicate that neuroestradiol is also important for the pulsatile release as well as the surge release of GnRH in female rhesus monkeys, in the present study, we examined whether neuroestradiol plays a role in the estrogen-induced LH surge in orchidectomized (ORX) male rhesus monkeys. Unlike in rodents, it is known that a high dose of estrogen treatment can result in the LH surge in ORX male rhesus monkeys. Results that the administration of the aromatase inhibitor, letrozole, failed to attenuate the estrogen-induced LH surge, suggest that unlike in ovariectomized females, neuroestrogens do not play a role in the LH surge experimentally induced by the exogenous estrogen treatment in ORX male monkeys.

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