PTCOG 胃肠道小组委员会下消化道恶性肿瘤共识声明。

IF 2.1 Q3 ONCOLOGY International Journal of Particle Therapy Pub Date : 2024-04-26 eCollection Date: 2024-03-01 DOI:10.1016/j.ijpt.2024.100019
J Isabelle Choi, Andrzej Wojcieszynski, Richard A Amos, Huan Giap, Smith Apisarnthanarax, Jonathan B Ashman, Aman Anand, Luis A Perles, Tyler Williamson, Shanmugasundaram Ramkumar, Jason Molitoris, Charles B Simone, Michael D Chuong
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引用次数: 0

摘要

目的:在下消化道(LGI)恶性肿瘤的最终治疗中,放疗与急性和晚期胃肠道(GI)、泌尿生殖系统、皮肤和血液毒性的巨大风险相关。质子束疗法(PBT)等先进的放射治疗技术能最大限度地保留有风险的关键器官的剂量,与光子疗法相比,能获得更有利的治疗比:国际粒子治疗合作组消化道小组委员会进行了一次系统的文献综述,并在此基础上就PBT在LGI恶性肿瘤中的应用提出了共识性建议:结果:共提出了 11 项关于应考虑使用 PBT 的临床适应症的建议,并附有支持性文献,对每项建议都进行了证据级别和推荐强度评估。此外,还提供了有关模拟、治疗计划和实施以及图像引导的详细技术指南:结论:PBT 可能对某些 LGI 恶性肿瘤患者有重要价值。需要更多临床数据来进一步阐明 PBT 对肛门癌和直肠癌患者的潜在益处。
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PTCOG Gastrointestinal Subcommittee Lower Gastrointestinal Tract Malignancies Consensus Statement.

Purpose: Radiotherapy delivery in the definitive management of lower gastrointestinal (LGI) tract malignancies is associated with substantial risk of acute and late gastrointestinal (GI), genitourinary, dermatologic, and hematologic toxicities. Advanced radiation therapy techniques such as proton beam therapy (PBT) offer optimal dosimetric sparing of critical organs at risk, achieving a more favorable therapeutic ratio compared with photon therapy.

Materials and methods: The international Particle Therapy Cooperative Group GI Subcommittee conducted a systematic literature review, from which consensus recommendations were developed on the application of PBT for LGI malignancies.

Results: Eleven recommendations on clinical indications for which PBT should be considered are presented with supporting literature, and each recommendation was assessed for level of evidence and strength of recommendation. Detailed technical guidelines pertaining to simulation, treatment planning and delivery, and image guidance are also provided.

Conclusion: PBT may be of significant value in select patients with LGI malignancies. Additional clinical data are needed to further elucidate the potential benefits of PBT for patients with anal cancer and rectal cancer.

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来源期刊
International Journal of Particle Therapy
International Journal of Particle Therapy Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.70
自引率
5.90%
发文量
23
审稿时长
20 weeks
期刊最新文献
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