在捷克共和国布尔诺市区栖息的蝙蝠中发现的布尔诺贷款病毒(BRNV)。

IF 2.6 4区 医学 Q3 INFECTIOUS DISEASES Infection Genetics and Evolution Pub Date : 2024-05-15 DOI:10.1016/j.meegid.2024.105604
Andrea Fořtová , Petra Straková , Jan Haviernik , Pavel Svoboda , Tomáš Bartonička , Jana Kvičerová , Daniel Růžek , Jiří Salát
{"title":"在捷克共和国布尔诺市区栖息的蝙蝠中发现的布尔诺贷款病毒(BRNV)。","authors":"Andrea Fořtová ,&nbsp;Petra Straková ,&nbsp;Jan Haviernik ,&nbsp;Pavel Svoboda ,&nbsp;Tomáš Bartonička ,&nbsp;Jana Kvičerová ,&nbsp;Daniel Růžek ,&nbsp;Jiří Salát","doi":"10.1016/j.meegid.2024.105604","DOIUrl":null,"url":null,"abstract":"<div><p>Bats are known reservoirs of various emerging pathogens, and have recently been found to host a novel hantavirus, named Brno loanvirus (BRNV), from the <em>Mammantavirinae</em> subfamily (family <em>Hantaviridae</em>, order <em>Bunyavirales</em>). Here we report BRNV detection in bats from the urban area of Brno, Czech Republic in March 2022. Specifically, we uncovered a high prevalence of BRNV (8.8%, 5/57) among hibernating bats (<em>Nyctalus noctula</em>) in urban area, which poses a risk of human exposure. The positive bats included adult females (3/9 positive), a juvenile female (1/32 positive), and an adult male (1/6 positive). All 10 juvenile males were negative. We used RT-qPCR to quantify the BRNV RNA levels in various bat organs, which yielded positive results for viral RNA in organs, including the kidneys, heart, spleen, brain, liver, lung, and gut, and in body cavity fluid. Among all tested organs, the liver showed the highest levels of viral RNA in 4 out of 5 animals examined (average Ct value of 20.8 ± 7.4).</p></div>","PeriodicalId":54986,"journal":{"name":"Infection Genetics and Evolution","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1567134824000558/pdfft?md5=2127f6f8c5e34b1b57d406f90b0612db&pid=1-s2.0-S1567134824000558-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Brno loanvirus (BRNV) in bats inhabiting the urban area of Brno, Czech Republic\",\"authors\":\"Andrea Fořtová ,&nbsp;Petra Straková ,&nbsp;Jan Haviernik ,&nbsp;Pavel Svoboda ,&nbsp;Tomáš Bartonička ,&nbsp;Jana Kvičerová ,&nbsp;Daniel Růžek ,&nbsp;Jiří Salát\",\"doi\":\"10.1016/j.meegid.2024.105604\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bats are known reservoirs of various emerging pathogens, and have recently been found to host a novel hantavirus, named Brno loanvirus (BRNV), from the <em>Mammantavirinae</em> subfamily (family <em>Hantaviridae</em>, order <em>Bunyavirales</em>). Here we report BRNV detection in bats from the urban area of Brno, Czech Republic in March 2022. Specifically, we uncovered a high prevalence of BRNV (8.8%, 5/57) among hibernating bats (<em>Nyctalus noctula</em>) in urban area, which poses a risk of human exposure. The positive bats included adult females (3/9 positive), a juvenile female (1/32 positive), and an adult male (1/6 positive). All 10 juvenile males were negative. We used RT-qPCR to quantify the BRNV RNA levels in various bat organs, which yielded positive results for viral RNA in organs, including the kidneys, heart, spleen, brain, liver, lung, and gut, and in body cavity fluid. Among all tested organs, the liver showed the highest levels of viral RNA in 4 out of 5 animals examined (average Ct value of 20.8 ± 7.4).</p></div>\",\"PeriodicalId\":54986,\"journal\":{\"name\":\"Infection Genetics and Evolution\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1567134824000558/pdfft?md5=2127f6f8c5e34b1b57d406f90b0612db&pid=1-s2.0-S1567134824000558-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infection Genetics and Evolution\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1567134824000558\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection Genetics and Evolution","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1567134824000558","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

众所周知,蝙蝠是各种新出现病原体的宿主,最近又发现了一种新型汉坦病毒,名为布尔诺贷款病毒(BRNV),属于马曼塔病毒亚科(Hantaviridae科,Bunyavirales目)。在此,我们报告了 2022 年 3 月在捷克共和国布尔诺市区的蝙蝠中检测到的 BRNV。具体来说,我们在城市地区冬眠的蝙蝠(Nyctalus noctula)中发现了较高的 BRNV 感染率(8.8%,5/57),这给人类带来了接触风险。呈阳性的蝙蝠包括成年雌性(3/9 呈阳性)、一只幼年雌性(1/32 呈阳性)和一只成年雄性(1/6 呈阳性)。所有 10 只幼年雄性蝙蝠均为阴性。我们使用 RT-qPCR 对蝙蝠各器官中的 BRNV RNA 含量进行了定量检测,结果显示肾、心、脾、脑、肝、肺、肠道等器官以及体腔液中的病毒 RNA 均呈阳性。在所有受检器官中,肝脏的病毒 RNA 含量最高(平均 Ct 值为 20.8 ± 7.4)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Brno loanvirus (BRNV) in bats inhabiting the urban area of Brno, Czech Republic

Bats are known reservoirs of various emerging pathogens, and have recently been found to host a novel hantavirus, named Brno loanvirus (BRNV), from the Mammantavirinae subfamily (family Hantaviridae, order Bunyavirales). Here we report BRNV detection in bats from the urban area of Brno, Czech Republic in March 2022. Specifically, we uncovered a high prevalence of BRNV (8.8%, 5/57) among hibernating bats (Nyctalus noctula) in urban area, which poses a risk of human exposure. The positive bats included adult females (3/9 positive), a juvenile female (1/32 positive), and an adult male (1/6 positive). All 10 juvenile males were negative. We used RT-qPCR to quantify the BRNV RNA levels in various bat organs, which yielded positive results for viral RNA in organs, including the kidneys, heart, spleen, brain, liver, lung, and gut, and in body cavity fluid. Among all tested organs, the liver showed the highest levels of viral RNA in 4 out of 5 animals examined (average Ct value of 20.8 ± 7.4).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Infection Genetics and Evolution
Infection Genetics and Evolution 医学-传染病学
CiteScore
8.40
自引率
0.00%
发文量
215
审稿时长
82 days
期刊介绍: (aka Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases -- MEEGID) Infectious diseases constitute one of the main challenges to medical science in the coming century. The impressive development of molecular megatechnologies and of bioinformatics have greatly increased our knowledge of the evolution, transmission and pathogenicity of infectious diseases. Research has shown that host susceptibility to many infectious diseases has a genetic basis. Furthermore, much is now known on the molecular epidemiology, evolution and virulence of pathogenic agents, as well as their resistance to drugs, vaccines, and antibiotics. Equally, research on the genetics of disease vectors has greatly improved our understanding of their systematics, has increased our capacity to identify target populations for control or intervention, and has provided detailed information on the mechanisms of insecticide resistance. However, the genetics and evolutionary biology of hosts, pathogens and vectors have tended to develop as three separate fields of research. This artificial compartmentalisation is of concern due to our growing appreciation of the strong co-evolutionary interactions among hosts, pathogens and vectors. Infection, Genetics and Evolution and its companion congress [MEEGID](http://www.meegidconference.com/) (for Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases) are the main forum acting for the cross-fertilization between evolutionary science and biomedical research on infectious diseases. Infection, Genetics and Evolution is the only journal that welcomes articles dealing with the genetics and evolutionary biology of hosts, pathogens and vectors, and coevolution processes among them in relation to infection and disease manifestation. All infectious models enter the scope of the journal, including pathogens of humans, animals and plants, either parasites, fungi, bacteria, viruses or prions. The journal welcomes articles dealing with genetics, population genetics, genomics, postgenomics, gene expression, evolutionary biology, population dynamics, mathematical modeling and bioinformatics. We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .
期刊最新文献
High HIV-1 genetic diversity and low prevalence of transmitted drug resistance among treatment-naive people living with HIV in Madagascar. Discovery of the first sea turtle adenovirus and turtle associated circoviruses. Feline bocaviruses found in Thailand have undergone genetic recombination for their evolutions. Genetic variation and population structure of Taenia multiceps (Coenurus cerebralis) based on mitochondrial cox1 gene: A comprehensive global analysis. Genomic surveillance of dengue virus in Benin.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1