FORMULATION AND EVALUATION OF NASAL INSITU-GEL OF ELETRIPTAN FOR THE TREATMENT OF MIGRAINE

Nasal in situ gel based formulations are those which upon administration get converted into gel by various mechanism like pH , Temperature & other factor. Eletriptan is BCS class 1 drug with lesser aqueous solubility which is used for Migrane. Existing market formulation include tablet for the same with less than 50 percentage bioavailability because of cytochrome induction and first pass metabolism. Mainly cause for failure of the formulation to achieve desired bioavailability and therapeutic action is because of first pass metabolism and cytochrome induction which can be avoided by nasal delivery. Polaxomer 407 and Carbopol 934 used to formulate the nasal in situ gel of Eletriptan by cold method of preparation. While polyethylene glycol400 increase the solubility of drug in polaxomer along with increasing the permeation through nasal membrane. Hence by formulating nasal in situ gel of Eletriptan we can avoid FTM and get brain targeted drug delivery for the migrane. KEYWORDS: Nasal in-situ gel, Eletriptan, Migraine, cytochrome induction, first pass metabolism, brain targeted drug delivery.