偏头痛患者的或然负变异与残像持续时间之间的关系

Simeon Giesen, Florian Rimmele, Tim P. Jürgens, Jörg Scheidt, Johannes Drescher, Ann-Kristin Leonhardt, Sophia Schulze, Birgit Harbeck, Wolfgang Meyer, B. Müller, Peter Kropp, Armin Keller
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摘要

众所周知,偏头痛患者会出现皮层电参数异常和视觉刺激后的残像持续现象。对偏头痛患者的或然负变异(CNV)和余像持续性的研究结果表明,这两种现象之间存在联系,并与偏头痛的病理机制有关。本研究旨在调查偏头痛患者中CNV早期成分(iCNV)与余像持续时间之间的关系。来自罗斯托克大学医学中心头痛中心的67名偏头痛患者接受了iCNV振幅、iCNV习惯化和余像持续时间的检查。研究发现,iCNV 振幅与残像持续时间之间存在关联,习惯化能力与残像持续时间之间也存在关联。习惯化能力不足与残像持续时间明显延长相关。从本研究结果中可以得出偏头痛病理生理学的结论。研究结果支持大脑皮层过度兴奋是低预激活水平的结果这一假设,这可能是偏头痛的诱因之一。此外,研究还评估了比CNV检查更简便快捷的余像检查是否可用作偏头痛患者的诊断工具或监测治疗过程的参数。
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Relationship between Contingent Negative Variation and afterimage duration in migraine patients
Abnormalities in electrocortical parameters and persistence of afterimage after visual stimulation are known to occur in migraine patients. The results of studies on Contingent Negative Variation (CNV) and afterimage persistence in migraine patients suggest a link between these two phenomena and a connection to the pathomechanism of migraine.To date, no studies have investigated both afterimage duration and CNV parameters in the same subjects. The aim of this study was to investigate the relationship between the early component of CNV (iCNV) and the duration of the afterimage in migraine patients.Sixty seven migraine patients from the headache center of the University of Rostock Medical Center were examined for iCNV amplitude, iCNV habituation and afterimage duration. The subjects also completed questionnaires developed for this study and the MIDAS (Migraine Disability Assessment) questionnaire.Associations were found between iCNV amplitude and afterimage duration and between habituation capacity and afterimage duration. A deficit in habituation capacity correlated with a significantly prolonged afterimage duration. Increased iCNV amplitude and prolonged afterimage duration were also significantly correlated.Conclusions about the pathophysiology of migraine can be drawn from the results of this study. The results support the hypothesis of cortical hyperexcitability as a consequence of a low pre-activation level, which may be a possible contributory cause of migraine. Furthermore, they allow assessment of whether the afterimage examination, which is easier and quicker to perform than the CNV examination, can be used as a diagnostic tool or as a parameter to monitor the course of therapy in people with migraine.
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