罗马尼亚长期饮酒患者的认知功能评估

Shandiz Morega, Claudiu-Marinel Ionele, Mihaela-Andreea Podeanu, Dan-Nicolae Florescu, Ion Rogoveanu
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摘要

酗酒是一个重大的健康问题,对社会经济有着显著的影响。长期饮酒后,如果停止饮酒或大幅减少饮酒量,就会出现酒精戒断综合征(AWS)。非酒精性脂肪肝(NAFLD)的特点是在没有饮酒史的人的肝细胞中出现大量脂质堆积。有证据表明,认知障碍与这两种疾病都有关联。本研究旨在使用小型精神状态检查(Mini-Mental State Examination,MMSE)评估非酒精性脂肪肝和酒精性肝病患者的认知功能障碍。这项研究涉及罗马尼亚克拉约瓦两家医院的 120 名住院患者。结果表明,非酒精性脂肪肝患者没有表现出MMSE测量的认知障碍(平均值=29.27,标准差=0.785)。相反,AWS 患者表现出更明显的认知功能障碍,入院时的平均 MMSE 得分为 16.60 ± 4.097,接受维生素 B1 和 B6 以及脑磷脂治疗 2 周后的平均 MMSE 得分为 24.60 ± 2.832。此外,我们的研究结果表明,饮酒者的认知功能障碍与临床症状的严重程度有关,本研究中震颤的严重程度就证明了这一点。两周的治疗和戒酒期不足以使认知功能恢复到正常水平。建议进行更长时间的观察研究。
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Assessment of Cognitive Function in Romanian Patients with Chronic Alcohol Consumption
Alcoholism presents a significant health concern with notable socioeconomic implications. Alcohol withdrawal syndrome (AWS) can manifest when individuals cease or drastically reduce their alcohol consumption after prolonged use. Non-alcoholic fatty liver disease (NAFLD) is characterized by substantial lipid accumulation in the liver cells of individuals with no history of alcohol consumption. There is evidence suggesting an association between cognitive impairment and both conditions. This study aimed to evaluate cognitive impairment in patients with NAFLD and AWS using the Mini-Mental State Examination (MMSE). This study involved 120 patients admitted to two hospitals in Craiova, Romania. Results indicated that patients with NAFLD did not exhibit cognitive impairment as measured by MMSE (Mean = 29.27, SD = 0.785). Conversely, patients with AWS showed more pronounced cognitive dysfunction, with a mean MMSE score at admission of 16.60 ± 4.097 and 24.60 ± 2.832 after 2 weeks under treatment with Vitamins B1 and B6 and Cerebrolysin. Additionally, our findings suggested that cognitive dysfunction among alcohol consumers was correlated with the severity of clinical symptoms, as demonstrated by the severity of tremors in our study. The two-week period under treatment and alcohol withdrawal was insufficient for cognitive function to return to normal levels. Observational studies on longer periods of time are advised.
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