上颌手术后纤毛囊肿 (PSCC):三例系列病例

Domenico Sfondrini, Fabio Pagella, Matteo Pellegrini, Martina Ghizzoni, Andrea Scribante, Chiara Tore, Stefano Marelli
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This study presents case series involving three surgical ciliated cysts located in the left maxilla, affecting two female patients (aged 49 and 55 years) and one male patient (aged 39 years). In all three cases, symptoms such as pain or swelling were mild and not consistently present. Two cases showed cyst development 10 and 15 years after implant placement, while one case was not associated with any surgical or traumatic event. CT scan identified well-defined unilocular lesions in the maxillary bone in each patient. Results. Histopathological examination of the surgical specimens confirmed the suspected diagnosis of a PSCC of maxilla. The cystic walls consisted of fibrous connective tissue with chronic inflammatory infiltrate, lined exclusively by a thin layer of ciliated pseudostratified columnar epithelium. In the third patient, it was not possible to rule out an unusual radicular cyst. Conclusions. 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摘要

简介手术后纤毛囊肿(PSCC)是一种上皮性囊肿,通常发生在上颌骨,但在极少数情况下也会影响下颌骨或其他面部骨骼。典型的诊断年龄为 40-50 岁,无性别倾向,平均囊肿发生时间约为手术或外伤后 10-15 年。在上颌骨外科手术或上颌骨骨折过程中,一些上皮呼吸细胞会被困在骨组织中。发病机制可能是炎症过程刺激上皮细胞增殖,导致渗透压差引起囊肿扩张。方法。本研究介绍了三例位于左上颌骨的手术纤毛囊肿系列病例,涉及两名女性患者(49 岁和 55 岁)和一名男性患者(39 岁)。在所有三例病例中,疼痛或肿胀等症状均较轻微,且并非持续存在。两例病例在植入假牙 10 年和 15 年后出现囊肿,一例病例与任何手术或创伤事件无关。CT 扫描在每位患者的上颌骨中都发现了界限清晰的单眼病变。结果手术标本的组织病理学检查证实了上颌骨 PSCC 的疑似诊断。囊壁由纤维结缔组织组成,伴有慢性炎症浸润,内衬仅有一层薄薄的纤毛假柱状上皮。在第三例患者中,无法排除不寻常的根状囊肿。结论。虽然PSCC在日常工作中并不常见,但临床医生在鉴别诊断牙源性颌骨囊肿和良性颌骨肿瘤时,应考虑到这种可能性,尤其是上颌区域曾接受过手术的患者。
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Maxillary Postsurgical Ciliated Cysts (PSCCs): A Series of Three Cases
Introduction. A postsurgical ciliated cyst (PSCC) is an epithelial cyst that usually develops in the maxilla, although in rare cases, it can affect the mandible or other facial bones. The typical age of diagnosis is 40-50 years, with no gender prevalence, and the mean cyst development occurs approximately 10-15 years following a surgical or traumatic event. Some epithelial respiratory cells can be trapped into the bone tissue during maxillary surgical procedures or maxillary fractures. The pathogenetic mechanism can be attributed to an inflammatory process that stimulates epithelial proliferation, leading to cyst expansion caused by osmotic pressure difference. Methods. This study presents case series involving three surgical ciliated cysts located in the left maxilla, affecting two female patients (aged 49 and 55 years) and one male patient (aged 39 years). In all three cases, symptoms such as pain or swelling were mild and not consistently present. Two cases showed cyst development 10 and 15 years after implant placement, while one case was not associated with any surgical or traumatic event. CT scan identified well-defined unilocular lesions in the maxillary bone in each patient. Results. Histopathological examination of the surgical specimens confirmed the suspected diagnosis of a PSCC of maxilla. The cystic walls consisted of fibrous connective tissue with chronic inflammatory infiltrate, lined exclusively by a thin layer of ciliated pseudostratified columnar epithelium. In the third patient, it was not possible to rule out an unusual radicular cyst. Conclusions. Although PSCCs are not commonly encountered in daily practice, clinicians should consider this possibility including it in the differential diagnosis of odontogenic jaw cysts and benign jaw tumors, particularly in patients who have undergone previous surgeries in the maxillary area.
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