Gabriele Sani, T. Callovini, O. M. Ferrara, Daniele Segatori, Stella Margoni, A. Simonetti, Francesco Maria Lisci, G. Marano, Alessia Fischetti, G. Kotzalidis, Federica Di Segni, Federica Fiaschè, D. Janiri, L. Moccia, G. Manfredi, Alessandro Alcibiade, Caterina Brisi, F. Grisoni, Gianmarco Stella, E. Bernardi, Andrea Brugnami, M. Ciliberto, M. C. Spera, R. Caso, Sara Rossi, Gianluca Boggio, Giulia Mastroeni, Francesca Abate, E. Conte, Anna Quintano, L. D. Chiara, Laura Monti, Giovanni Camardese, Lucio Rinaldi, A. Koukopoulos, D. Chieffo, G. Angeletti, Marianna Mazza
{"title":"孕期服用抗精神病药物与畸形率升高和母婴结局恶化有关吗?系统回顾","authors":"Gabriele Sani, T. Callovini, O. M. Ferrara, Daniele Segatori, Stella Margoni, A. Simonetti, Francesco Maria Lisci, G. Marano, Alessia Fischetti, G. Kotzalidis, Federica Di Segni, Federica Fiaschè, D. Janiri, L. Moccia, G. Manfredi, Alessandro Alcibiade, Caterina Brisi, F. Grisoni, Gianmarco Stella, E. Bernardi, Andrea Brugnami, M. Ciliberto, M. C. Spera, R. Caso, Sara Rossi, Gianluca Boggio, Giulia Mastroeni, Francesca Abate, E. Conte, Anna Quintano, L. D. Chiara, Laura Monti, Giovanni Camardese, Lucio Rinaldi, A. Koukopoulos, D. Chieffo, G. Angeletti, Marianna Mazza","doi":"10.2174/1570159x22666240516151449","DOIUrl":null,"url":null,"abstract":"\n\nThere is much debate about continuing antipsychotic medication in patients who need it when\nthey become pregnant because benefits must be weighed against potential teratogenic and malformation\neffects related to antipsychotics themselves. To address this, we conducted a systematic review on the\nPubMed, PsycINFO and CINHAL databases and the ClinicalTrials.gov register using the following strategy:\n(toxicity OR teratogenicity OR malformation* OR \"birth defect*\" OR \"congenital abnormality\" OR\n\"congenital abnormalities\" OR \"brain changes\" OR \"behavioral abnormalities\" OR \"behavioral abnormalities\")\nAND antipsychotic* AND (pregnancy OR pregnant OR lactation OR delivery OR prenatal OR\nperinatal OR post-natal OR puerperium) on September 27, 2023. We found 38 studies to be eligible. The\noldest was published in 1976, while most articles were recent. Most studies concluded that the antipsychotics,\nespecially the second-generation antipsychotics, were devoid of teratogenic potential, while few\nstudies were inconclusive and recommended replication. Most authoritative articles were from the Boston\narea, where large databases were implemented to study the malformation potential of psychiatric drugs.\nOther reliable databases are from Northern European registers. Overall conclusions are that antipsychotics\nare no more related to malformations than the disorders themselves; most studies recommend that\nthere are no reasons to discontinue antipsychotic medications in pregnancy.\n","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is Antipsychotic Drug Use During Pregnancy Associated with Increased\\nMalformation Rates and Worsening of Maternal and Infant Outcomes? A\\nSystematic Review\",\"authors\":\"Gabriele Sani, T. Callovini, O. M. Ferrara, Daniele Segatori, Stella Margoni, A. Simonetti, Francesco Maria Lisci, G. Marano, Alessia Fischetti, G. Kotzalidis, Federica Di Segni, Federica Fiaschè, D. Janiri, L. Moccia, G. Manfredi, Alessandro Alcibiade, Caterina Brisi, F. Grisoni, Gianmarco Stella, E. Bernardi, Andrea Brugnami, M. Ciliberto, M. C. Spera, R. Caso, Sara Rossi, Gianluca Boggio, Giulia Mastroeni, Francesca Abate, E. Conte, Anna Quintano, L. D. Chiara, Laura Monti, Giovanni Camardese, Lucio Rinaldi, A. Koukopoulos, D. Chieffo, G. Angeletti, Marianna Mazza\",\"doi\":\"10.2174/1570159x22666240516151449\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nThere is much debate about continuing antipsychotic medication in patients who need it when\\nthey become pregnant because benefits must be weighed against potential teratogenic and malformation\\neffects related to antipsychotics themselves. To address this, we conducted a systematic review on the\\nPubMed, PsycINFO and CINHAL databases and the ClinicalTrials.gov register using the following strategy:\\n(toxicity OR teratogenicity OR malformation* OR \\\"birth defect*\\\" OR \\\"congenital abnormality\\\" OR\\n\\\"congenital abnormalities\\\" OR \\\"brain changes\\\" OR \\\"behavioral abnormalities\\\" OR \\\"behavioral abnormalities\\\")\\nAND antipsychotic* AND (pregnancy OR pregnant OR lactation OR delivery OR prenatal OR\\nperinatal OR post-natal OR puerperium) on September 27, 2023. We found 38 studies to be eligible. The\\noldest was published in 1976, while most articles were recent. Most studies concluded that the antipsychotics,\\nespecially the second-generation antipsychotics, were devoid of teratogenic potential, while few\\nstudies were inconclusive and recommended replication. 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Is Antipsychotic Drug Use During Pregnancy Associated with Increased
Malformation Rates and Worsening of Maternal and Infant Outcomes? A
Systematic Review
There is much debate about continuing antipsychotic medication in patients who need it when
they become pregnant because benefits must be weighed against potential teratogenic and malformation
effects related to antipsychotics themselves. To address this, we conducted a systematic review on the
PubMed, PsycINFO and CINHAL databases and the ClinicalTrials.gov register using the following strategy:
(toxicity OR teratogenicity OR malformation* OR "birth defect*" OR "congenital abnormality" OR
"congenital abnormalities" OR "brain changes" OR "behavioral abnormalities" OR "behavioral abnormalities")
AND antipsychotic* AND (pregnancy OR pregnant OR lactation OR delivery OR prenatal OR
perinatal OR post-natal OR puerperium) on September 27, 2023. We found 38 studies to be eligible. The
oldest was published in 1976, while most articles were recent. Most studies concluded that the antipsychotics,
especially the second-generation antipsychotics, were devoid of teratogenic potential, while few
studies were inconclusive and recommended replication. Most authoritative articles were from the Boston
area, where large databases were implemented to study the malformation potential of psychiatric drugs.
Other reliable databases are from Northern European registers. Overall conclusions are that antipsychotics
are no more related to malformations than the disorders themselves; most studies recommend that
there are no reasons to discontinue antipsychotic medications in pregnancy.
期刊介绍:
Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience.
The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.