Össur Ingi Emilsson, Henrik Johansson, A. Johannessen, Christer Janson, Andreas Palm, Karl A. Franklin, Anna Oudin, F. Gómez Real, M. Holm, Thorarinn Gíslason, Eva Lindberg, R. Jõgi, V. Schlünssen, Francisco Javier Callejas-González, Jingwen Zhang, Andrei Malinovschi, C. Svanes, Magnus Ekström
{"title":"两代人的咳嗽遗传率:RHINESSA 研究","authors":"Össur Ingi Emilsson, Henrik Johansson, A. Johannessen, Christer Janson, Andreas Palm, Karl A. Franklin, Anna Oudin, F. Gómez Real, M. Holm, Thorarinn Gíslason, Eva Lindberg, R. Jõgi, V. Schlünssen, Francisco Javier Callejas-González, Jingwen Zhang, Andrei Malinovschi, C. Svanes, Magnus Ekström","doi":"10.1183/23120541.00071-2024","DOIUrl":null,"url":null,"abstract":"Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/non-productive).The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questionnaires in 2000 and 2 010, and 8176 offspring ≥20 years answering similar questionnaires in 2012–2019. Chronic cough was categorized as productive or non-productive (dry) cough. Associations between parental and offspring cough were analyzed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; center and family.Among parents with non-productive cough, 11% of their offspring reported non-productive cough, compared with 7% of offspring to parents without non-productive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20–2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07–1.67). No associations were found between parent productive cough – offspring non-productive cough, nor between parent non-productive cough – offspring productive cough.Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the non-productive cough in parent associates only with non-productive cough in offspring, and the same applied for productive cough.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Heritability of cough across two generations: the RHINESSA study\",\"authors\":\"Össur Ingi Emilsson, Henrik Johansson, A. Johannessen, Christer Janson, Andreas Palm, Karl A. Franklin, Anna Oudin, F. Gómez Real, M. Holm, Thorarinn Gíslason, Eva Lindberg, R. Jõgi, V. Schlünssen, Francisco Javier Callejas-González, Jingwen Zhang, Andrei Malinovschi, C. Svanes, Magnus Ekström\",\"doi\":\"10.1183/23120541.00071-2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/non-productive).The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questionnaires in 2000 and 2 010, and 8176 offspring ≥20 years answering similar questionnaires in 2012–2019. Chronic cough was categorized as productive or non-productive (dry) cough. Associations between parental and offspring cough were analyzed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; center and family.Among parents with non-productive cough, 11% of their offspring reported non-productive cough, compared with 7% of offspring to parents without non-productive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20–2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07–1.67). No associations were found between parent productive cough – offspring non-productive cough, nor between parent non-productive cough – offspring productive cough.Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the non-productive cough in parent associates only with non-productive cough in offspring, and the same applied for productive cough.\",\"PeriodicalId\":11739,\"journal\":{\"name\":\"ERJ Open Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ERJ Open Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1183/23120541.00071-2024\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ERJ Open Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1183/23120541.00071-2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Heritability of cough across two generations: the RHINESSA study
Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/non-productive).The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questionnaires in 2000 and 2 010, and 8176 offspring ≥20 years answering similar questionnaires in 2012–2019. Chronic cough was categorized as productive or non-productive (dry) cough. Associations between parental and offspring cough were analyzed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; center and family.Among parents with non-productive cough, 11% of their offspring reported non-productive cough, compared with 7% of offspring to parents without non-productive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20–2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07–1.67). No associations were found between parent productive cough – offspring non-productive cough, nor between parent non-productive cough – offspring productive cough.Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the non-productive cough in parent associates only with non-productive cough in offspring, and the same applied for productive cough.
期刊介绍:
ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.