全身炎症反应指数与老年高血压患者骨质密度、骨质疏松症和未来骨折风险的关系。

Huimin Ma, Xintian Cai, Junli Hu, Shuaiwei Song, Qing Zhu, Yingying Zhang, Rui Ma, Di Shen, Wenbo Yang, Pan Zhou, Delian Zhang, Qin Luo, Jing Hong, Nanfang Li
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引用次数: 0

摘要

目的本研究旨在探讨老年高血压患者的全身炎症反应指数(SIRI)与骨矿物质密度(BMD)、骨质疏松症和未来骨折风险之间的关系。方法纳入 2021 年 1 月至 2023 年 12 月期间在我院就诊并完成 BMD 筛查的老年高血压患者(年龄≥60 岁)。结果多元线性回归表明,SIRI 水平与腰1 BMD(β = -0.15,95% CI:-0.24,-0.05)、腰2 BMD(β = -0.15,95% CI:-0.24,-0.05)、腰3 BMD(β =-1.35,95% CI:-0.23,-0.02)、腰4 BMD(β =-0.11,95% CI:-0.30,-0.10)、股骨颈 BMD(β =-0.11,95% CI:-0.18,-0.05)和沃德三角区 BMD(β =-0.12,95% CI:-0.20,-0.05)。此外,我们还观察到,SIRI 与老年高血压患者未来的骨折风险呈正相关。具体来说,SIRI 与重大骨质疏松性骨折(β = 0.33)和髋部骨折(β = 0.25)的风险增加有关。逻辑回归分析表明,在对混杂因素进行充分调整后,SIRI 水平与骨质疏松症风险增加之间存在关联(OR = 1.60,95% CI = 1.37,1.87)。然而,还需要进一步的研究来证实这些发现。
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Association of systemic inflammatory response index with bone mineral density, osteoporosis, and future fracture risk in elderly hypertensive patients.
OBJECTIVES This study sought to investigate the relationship between the systemic inflammatory response index (SIRI) and bone mineral density (BMD), osteoporosis, and future fracture risk in elderly hypertensive patients. METHODS Elderly hypertensive patients (age ≥60 years) who attended our hospital between January 2021 and December 2023 and completed BMD screening were included in the study. Analyses were performed with multivariate logistic and linear regression. RESULTS The multiple linear regression indicated that SIRI levels were significantly negatively correlated with lumbar 1 BMD (β = -0.15, 95% CI: -0.24, -0.05), lumbar 2 BMD (β = -0.15, 95% CI: -0.24, -0.05), lumbar 3 BMD (β = -1.35, 95% CI: -0.23, -0.02), lumbar 4 BMD (β = -0.11, 95% CI: -0.30, -0.10), femur neck BMD (β = -0.11, 95% CI: -0.18, -0.05) and Ward's triangle BMD (β = -0.12, 95% CI: -0.20, -0.05) among elderly hypertensive patients, after fully adjusting for confounders. Furthermore, we observed that SIRI was positively associated with future fracture risk in elderly hypertensive patients. Specifically, SIRI was associated with an increased risk of major osteoporotic fractures (β = 0.33) and hip fractures (β = 0.25). The logistic regression analysis indicated that there is an association between the SIRI level and an increased risk of osteoporosis (OR = 1.60, 95% CI = 1.37, 1.87), after fully adjusting for confounders. CONCLUSIONS Our findings indicate a potential association between SIRI and BMD, osteoporosis, and the risk of future fractures in elderly hypertensive patients. However, further studies are warranted to confirm these findings.
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